Munhu CYP2C9 uye VKORC1 Gene Polymorphism

Tsanangudzo Pfupi:

Kiti iyi inoshanda kune in vitro qualitative diagnosis yepolymorphism yeCYP2C9*3 (rs1057910, 1075A>C) uye VKORC1 (rs9923231, -1639G>A) mune genomic DNA yemasampuli eropa revanhu.


Product Detail

Product Tags

Product name

HWTS-GE014A-Human CYP2C9 uye VKORC1 Gene Polymorphism Detection Kit (Fluorescence PCR)

Chitupa

CE/TFDA

Epidemiology

Warfarin ndeyemumuromo anticoagulant inowanzoshandiswa mukiriniki yekudzidzira parizvino, iyo inonyanya kuitirwa kudzivirira uye kurapwa kwezvirwere zvethromboembolic.Nekudaro, warfarin ine hwindo rekurapa shoma uye inosiyana zvakanyanya pakati pemarudzi akasiyana uye vanhu.Nhamba dzakaratidza kuti mutsauko wedosi yakagadzikana muvanhu vakasiyana inogona kudarika nguva dze20.Kubuda ropa kwakashata kunoitika mu15.2% yevarwere vanotora warfarin gore rega rega, iyo 3.5% yavo inobuda ropa rinouraya.Pharmacogenomic zvidzidzo zvakaratidza kuti genetic polymorphism yechinangwa enzyme VKORC1 uye metabolic enzyme CYP2C9 yewarfarin chinhu chakakosha chinokanganisa mutsauko wedosi yewarfarin.Warfarin inhibitor chaiyo yevhitamini K epoxide reductase (VKORC1), uye nokudaro inhibits clotting factor synthesis inosanganisira vitamin K uye inopa anticoagulation.Nhamba huru yezvidzidzo zvakaratidza kuti gene polymorphism yeVKORC1 mutsigiri ndiyo inonyanya kukosha inokanganisa nhangemutange uye misiyano yemunhu muyero inodiwa yewarfarin.Warfarin inogadziriswa neCYP2C9, uye inochinja inononoka metabolism ye warfarin.Vanhu vanoshandisa warfarin vane njodzi huru (yakapetwa kaviri kusvika katatu kumusoro) yekubuda ropa padanho rekutanga rekushandisa.

Channel

FAM VKORC1 (-1639G>A)
CY5 CYP2C9*3
VIC/HEX IC

Technical Parameters

Storage Mvura: ≤-18℃
Sherufu-hupenyu 12 mwedzi
Type Type Fresh EDTA anticoagulated ropa
CV ≤5.0%
LoD 1.0ng/μL
Zvakananga Iko hakuna kuyambuka-reactivity pamwe nekumwe kunoenderana kutevedzana kwegenome yemunhu (yemunhu CYP2C19 gene, yemunhu RPN2 gene);shanduko yeCYP2C9*13 uye VKORC1 (3730G>A) kunze kwekuonekwa kwetiti iyi.
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BioRad CFX Opus 96 Chaiyo-Nguva PCR System

Kuyerera Kwebasa

Inokurudzirwa kubvisa reagent: Macro & Micro-Test Viral DNA/RNA Kit(HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) uye Macro & Micro-Test Automatic Nucleic Acid Extractor(HWTS- 3006).


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