Munhu CYP2C19 Gene Polymorphism

Tsanangudzo Pfupi:

Iyi kit inoshandiswa in vitro qualitative kuonekwa kwepolymorphism yeCYP2C19 majini CYP2C19*2 (rs4244285, c.681G>A), CYP2C19*3 (rs4986893, c.636G>A), CYP2C19*2 c685 (rs68, 1485) > T) mune genomic DNA yemasampuli eropa revanhu.


Product Detail

Product Tags

Product name

HWTS-GE012A-Munhu CYP2C19 Gene Polymorphism Detection Kit (Fluorescence PCR)

Chitupa

CE/TFDA

Epidemiology

CYP2C19 ndeimwe yemishonga yakakosha metabolizing enzymes mumhuri yeCYP450.Mazhinji endogenous substrates uye angangoita 2% yemishonga yekiriniki inogadziriswa neCYP2C19, senge metabolism ye antiplatelet aggregation inhibitors (senge clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, nezvimwewo. zvinodhaka zvinoenderana.Aya mapoinzi ekuchinja kwe * 2 (rs4244285) uye * 3 (rs4986893) anokonzera kurasikirwa kweiyo enzyme yakavharidzirwa neCYP2C19 gene uye kushaya simba kwe metabolic substrate kugona, uye kuwedzera kuwanda kweropa, kuitira kuti ikonzere kukanganisa kwezvinodhaka zvine chekuita ne kuwedzera kweropa.* 17 (rs12248560) inogona kuwedzera basa re enzyme rakavharidzirwa neCYP2C19 gene, kugadzirwa kwematabolites anoshanda, uye kuwedzera platelet aggregation inhibition uye kuwedzera njodzi yekubuda ropa.Kune vanhu vanononoka metabolism yezvinodhaka, kutora madosi akajairwa kwenguva yakareba kunokonzeresa muchetura uye mhedzisiro: kunyanya kukuvara kwechiropa, hematopoietic system kukuvara, kukuvara kwepakati tsinga, nezvimwewo, izvo zvinogona kutungamira kurufu mumatambudziko akaomarara.Zvinoenderana nekusiyana kwega kwega mune inofananidzwa yemetabolism yezvinodhaka, inowanzo kupatsanurwa kuita ina phenotypes, zvinoti ultra-fast metabolism (UM, * 17 / * 17, * 1 / * 17), kukurumidza metabolism (RM, * 1 / * 1). ), metabolism yepakati (IM, *1/*2, *1/*3), inononoka metabolism (PM, *2/*2, *2/*3, *3/*3).

Channel

FAM CYP2C19*2
CY5 CYP2C9*3
ROX CYP2C19*17
VIC/HEX IC

Technical Parameters

Storage Mvura: ≤-18℃
Sherufu-hupenyu 12 mwedzi
Type Type Fresh EDTA anticoagulated ropa
CV ≤5.0%
LoD 1.0ng/μL
Zvakananga Iko hakuna kuyambuka-reactivity nemamwe anowirirana zvakanyanya (CYP2C9 gene) mune genome remunhu.Iko kuchinja kweCYP2C19 * 23, CYP2C19 * 24 uye CYP2C19 * 25 nzvimbo dziri kunze kwekuonekwa kwetikiti iyi hazvina simba pakuona maitiro ekiti iyi.
Zvishandiso Zvishandiso Applied Biosystems 7500 Chaiyo-Nguva PCR Systems

Applied Biosystems 7500 Fast Real-Time PCR Systems

QuantStudio®5 Chaiyo-Nguva PCR Systems

SLAN-96P Chaiyo-Nguva PCR Systems

LightCycler®480 Chaiyo-Nguva PCR system

LineGene 9600 Plus Chaiyo-Nguva PCR Detection System

MA-6000 Chaiyo-Nguva Quantitative Thermal Cycler

BioRad CFX96 Chaiyo-Nguva PCR System

BioRad CFX Opus 96 Chaiyo-Nguva PCR System

Kuyerera Kwebasa

Inokurudzirwa kuburitsa reagent: Macro & Micro-Test General DNA/RNA Kit (HWTS-3019) (iyo inogona kushandiswa neMacro & Micro-Test Automatic Nucleic Acid Extractor (HWTS-EQ011)) naJiangsu Macro & Micro-Test Med-Tech Co., Ltd. Iyo yekubvisa inofanira kutorwa maererano nemirairo.Iyo yekubvisa sampuli vhoriyamu i200μL, uye yakakurudzirwa elution vhoriyamu i100μL.

Inokurudzirwa yekuchera reagent: Wizard® Genomic DNA Purification Kit (Catalog Nhamba: A1120) nePromega, Nucleic Acid Extraction kana Purification Reagent(YDP348) neTiangen Biotech(Beijing) Co.,Ltd.inofanira kutorwa maererano nemirairo yekuchera, uye yakakurudzirwa yekuwedzera vhoriyamu i200 μL uye yakakurudzirwa elution vhoriyamu i160 μL.


  • Zvakapfuura:
  • Zvinotevera:

  • Nyora meseji yako pano ugotitumira