Human Cyp2c9 uye VKorc1 Gene Polymorphism
Chigadzirwa Zita
HWTS-GE014A-Human Cyp2c9 uye VKorc1 Gene Polymorphism Kuona Kit (Fluorescence PCR)
Chitupa
CE / TFDA
Epidemiology
WATFARIN MUMWE MUNHU ANOGONESA ZVINOGONESESWA ZVINOGONESESWA MUCHENYU CLINICAL PRISTE parizvino, izvo zvinonyanya kuitirwa kudzivirira uye kurapwa kwezvirwere zvezvirwere. Nekudaro, warfarin ine hwindo rakareba rekurapa uye rinosiyana kwazvo pakati pemadzinza akasiyana uye vanhu vamwe vanhu. Statistics yakaratidza kuti kusiyana kwekugadzikana kwedhoti muvanhu vakasiyana kunogona kupfuura kakawanda. Iyo yekugadzirisa maitiro anoitika mu15.2% yevarwere vanotora kurwisa kurwa gore rega rega, yeiyo 3.5% inokudziridza kufa nekuuraya kufa. Zvidzidzo zvePharmacogemic zvakaratidza kuti genetic polymorphism yeiyo enzyme vkorc1 uye metabolic enzarin chinhu chakakosha chinokanganisa mutsauko wehondo yehondo. Warfarin inyanzvi yeVitamini K epoxide Ridctase (VKKorc1), uye nokudaro inhibits cletting cletting phivisis inosanganisira vitamini k uye inopa anticoagation. Nhamba huru yezvidzidzo zvakaratidza kuti gene polymorphism yeVKorc1 puroter ndiyo yakakosha chinhu chinokanganisa mujaho uye musiyano wega mudhara unodikanwa wehondo. Warfarin iri metabolized ne cyp2c9, uye yayo mutanji zvishoma nezvishoma metabolism yehondo. Vanhu vari kushandisa warfarin vane njodzi yepamusoro (kaviri kakapetwa katatu kumusoro) yekubuda ropa mune yekutanga nhanho yekushandiswa.
Chiteshi
| Nhamo | VKKC1 (-1639G> A) |
| CY5 | Cyp2c9 * 3 |
| Vic / Hex | IC |
Technical parameter
| Chengetedza | Mvura: ≤-18 ℃ |
| Shefu-Hupenyu | Mwedzi gumi nemaviri |
| Type Type | New Edta Anotarisirwa Ropa |
| CV | ≤5.0% |
| Lod | 1.0ng / μl |
| Chokwadi | Iko hakuna kuyambuka-kuita pamwe nedzimwe zvinoshandiswa zvakanyanya kutevedzana kweGenome (Human Cyp2c19 Gente, Human RPN2 Gene); mutation of Cyp2c9 * 13 uye vkorc1 (3730g> a) kunze kwekuonekwa kweiyi kit iyi |
| Zviridzwa zvinoshanda | Yakaiswa Biosystems 7500 chaiyo-nguva PCR system Yakaiswa biosystems 7500 nekukurumidza chaiyo-nguva pcr system Quantstudio®5 chaiyo-nguva PCR system Slan-96p chaiyo-nguva pcr system Lightcycler ®480 chaiyo-nguva PCR system Linegene 9600 Plus Real-Nguva PRR Kuongororwa system Ma-6000 chaiyo-nguva huwandu hweThebrary cyler Biorad cfx96 chaiyo-nguva pcr system Biorad cfx opus 96 chaiyo-nguva pcr system |
Shanda kuyerera
Yakakurudzirwa Reaget Reagent: Macro & micro-test-test virara / rwts-3001, hwts-3004-48, 3006).
