Kuumbwa kweMajini eCYP2C19 eMunhu

CYP2C19 ndeimwe yema enzymes akakosha ekugadzirisa mishonga mumhuri yeCYP450. Mazhinji ma substrates endogenous uye angangoita 2% yemishonga yekiriniki inogadziriswa neCYP2C19, senge metabolism ye antiplatelet aggregation inhibitors (senge clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, nezvimwewo. CYP2C19 gene polymorphisms inewo musiyano mukugona kwe metabolism yemishonga ine chekuita nayo. Izvi point mutations zve *2 (rs4244285) uye *3 (rs4986893) zvinokonzera kurasikirwa kwe enzyme activity yakanyorwa neCYP2C19 gene uye kushaya simba kwe metabolic substrate ability, uye kuwedzera huwandu hweropa, zvekuti zvinokonzera kusagadzikana kwemishonga ine chekuita nehuwandu hweropa. *17 (rs12248560) inogona kuwedzera enzyme activity yakanyorwa neCYP2C19 gene, kugadzirwa kwe active metabolites, uye kuwedzera platelet aggregation inhibition uye kuwedzera njodzi yekubuda ropa. Kune vanhu vane mishonga inononoka kushandiswa, kutora mishonga kwenguva yakareba kunokonzera chepfu yakakura uye migumisiro yakaipa: kunyanya kukuvara kwechiropa, kukuvara kwe hematopoietic system, kukuvara kwe central nervous system, nezvimwewo, izvo zvinogona kukonzera rufu muzviitiko zvakakomba. Zvichienderana nekusiyana kwega kwega mukushandiswa kwemishonga inoenderana, inowanzo kamurwa kuita ma phenotypes mana, anoti ultra-fast metabolism (UM,*17/*17,*1/*17), fast metabolism (RM,*1/*1), intermediate metabolism (IM, *1/*2, *1/*3), slow metabolism (PM, *2/*2, *2/*3, *3/*3).