KRAS 8 Mutations

Mapoinzi ekuchinja muKRAS gene akawanikwa mune akati wandei emhando dzemamota emunhu, angangoita 17% ~ 25% mutation rate mubundu, 15% ~ 30% mutation rate muvarwere vekenza yemapapu, 20% ~ 50% mutation rate mu colorectal cancer. varwere.Nekuti P21 protein yakavharidzirwa neK-ras gene iri pasi penzira yeEGFR yekusaina, mushure meK-ras gene mutation, nzira yekudzika yepasi inogara ichiitwa uye haina kukanganiswa neiyo kumusoro kwakanangwa mishonga paEGFR, zvichikonzera kuenderera. kuwanda kwakashata kwemasero.Shanduko muK-ras gene kazhinji inopa kuramba kune EGFR tyrosine kinase inhibitors muvarwere vekenza yemapapu uye kuramba anti-EGFR antibody zvinodhaka mune colorectal cancer varwere.Muna 2008, National Comprehensive Cancer Network (NCCN) yakapa kiriniki yekudzidzira gomarara recancer, iyo yakaratidza kuti nzvimbo dzekuchinja dzinoita kuti K-ras ishandiswe dzinonyanya kuwanikwa mucodons 12 uye 13 eexon 2, uye yakakurudzira kuti varwere vese vane advanced metastatic colorectal cancer vanogona kuongororwa K-ras mutation vasati varapwa.Naizvozvo, kuona nekukurumidza uye kwakaringana kweK-ras gene mutation kune kukosha kukuru mukutungamira kwemishonga yekiriniki.Iyi kit inoshandisa DNA seyekuongororwa sampuli kuti ipe ongororo yemhando yekuchinja mamiriro, iyo inogona kubatsira varapi mukuongorora colorectal cancer, cancer yemapapu uye vamwe varwere vebundu vanobatsirwa nemishonga yakanangwa.Mhedzisiro yemhedzisiro yekiti ndeyekuongororwa kwekiriniki chete uye haifanirwe kushandiswa seyo chete hwaro hwekurapwa kwega kwevarwere.Varapi vanofanira kuita mutongo wakakwana pamusoro pezvabuda pabvunzo zvichibva pazvinhu zvakaita semamiriro emurwere, zviratidzo zvemushonga, mhinduro yekurapwa uye zvimwe zviratidzo zvemurabhoritari.