KRAS 8 Kuchinja

Kuchinja kwemapoinzi mujini reKRAS kwakawanikwa mumhando dzakasiyana dzegomarara revanhu, huwandu hwe17% ~ 25% mugomarara, huwandu hwe15% ~ 30% mugomarara remapapu, huwandu hwe20% ~ 50% mugomarara recolorectal. Nekuti puroteni yeP21 inonyorwa nejini reK-ras iri pasi penzira yeEGFR signaling, mushure mekuchinja kwejini reK-ras, nzira yesignali yekudzika inogara ichishandiswa uye haikanganisirwi nemishonga inotarirwa kumusoro paEGFR, zvichikonzera kuwanda kwemasero ane kenza. Kuchinja kwejini reK-ras kunowanzo kupa kuramba kweEGFR tyrosine kinase inhibitors muvarwere vekenza yemapapu uye kuramba mishonga yekudzivirira ma antibodies eEGFR muvarwere vekenza yecolorectal. Muna 2008, National Comprehensive Cancer Network (NCCN) yakaburitsa gwara rekurapa kenza yemudumbu, iro rakaratidza kuti nzvimbo dzinokonzera kuchinja kwemasero eropa dzinoita kuti K-ras ishande dziri mu codons 12 ne13 ye exon 2, uye rakakurudzira kuti varwere vese vane kenza yemudumbu yemudumbu inogona kuongororwa K-ras mutation vasati varapwa. Nokudaro, kuona nekukurumidza uye kwakarurama K-ras gene mutation kwakakosha zvikuru mukurapa kwekiriniki. Kit iyi inoshandisa DNA semuyero wekuona kuti chirwere ichi chakaita sei, izvo zvinogona kubatsira vanachiremba mukuongorora kenza yemudumbu, kenza yemapapu nevamwe varwere vane bundu vanobatsirwa nemishonga inotarirwa. Mhedzisiro yekuedzwa kwekit iyi ndeyekutarisa chete uye haifanirwe kushandiswa senzira chete yekurapa varwere. Vanachiremba vanofanirwa kuita sarudzo dzakakwana pamhedzisiro yebvunzo zvichibva pazvinhu zvakaita semamiriro emurwere, zviratidzo zvemushonga, mhinduro yekurapa nezvimwe zviratidzo zvebvunzo zverabhoritari.