KRAS 8 Mutations

Mapoinzi ekuchinja muKRAS gene akawanikwa mune akati wandei emhando dzemamota emunhu, angangoita 17% ~ 25% mutation rate mubundu, 15% ~ 30% mutation rate muvarwere vekenza yemapapu, 20% ~ 50% mutation rate mune colorectal cancer varwere. Nemhaka yokuti puroteni yeP21 yakavharidzirwa neK-ras gene iri pasi penzira yeEGFR yechiratidzo, mushure meK-ras gene mutation, nzira yechiratidzo yepasi inogara ichishandiswa uye haibatsirwi nemishonga yakananga kumusoro kweEGFR, zvichiita kuti masero arambe achiwedzera. Shanduko muK-ras gene kazhinji inopa kuramba kune EGFR tyrosine kinase inhibitors muvarwere vekenza yemapapu uye kuramba anti-EGFR antibody zvinodhaka mune colorectal cancer varwere. Muna 2008, National Comprehensive Cancer Network (NCCN) yakapa nhungamiro yekiriniki yekurapa cancer colorectal, iyo yakataura kuti nzvimbo dzekuchinja dzinokonzeresa kuti K-ras ishandiswe dzinonyanya kuwanikwa mucodons 12 uye 13 eexon 2, uye yakakurudzira kuti varwere vese vane advanced metastatic colorectal cancer vaongororwe mutation yeK-ras. Naizvozvo, kuona nekukurumidza uye kwakaringana kweK-ras gene mutation kune kukosha kukuru mukutungamira kwemishonga yekiriniki. Iyi kit inoshandisa DNA seyekuongororwa sampuli kuti ipe ongororo yemhando yekuchinja mamiriro, iyo inogona kubatsira varapi mukuongorora colorectal cancer, cancer yemapapu uye vamwe varwere vebundu vanobatsirwa nemishonga yakanangwa. Mhedzisiro yemhedzisiro yekiti ndeyekuongororwa kwekiriniki chete uye haifanirwe kushandiswa seyo chete hwaro hwekurapwa kwega kwevarwere. Varapi vanofanira kuita mutongo wakakwana pamusoro pezvabuda pabvunzo zvichibva pazvinhu zvakaita semamiriro emurwere, zviratidzo zvemushonga, mhinduro yekurapwa uye zvimwe zviratidzo zvemurabhoritari.