Munhu BCR-ABL Fusion Gene Mutation

Tsanangudzo Pfupi:

Iyi kit inokodzera kuongororwa kwep190, p210 uye p230 isoforms yeBCR-ABL fusion gene mumasampure emapfupa emunhu.


Product Detail

Product Tags

Product name

HWTS-GE010A-Munhu BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)

Epidemiology

Chronic myelogenousleukemia (CML) chirwere chakashata chechirwere chehematopoietic stem masero.Vanopfuura 95% yevarwere veCML vanotakura Philadelphia chromosome (Ph) mumasero avo eropa.Chirwere chikuru cheCML chinotevera: BCR-ABL fusion gene inoumbwa nekushandurwa pakati peabl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) paruoko rurefu rwechromosome 9 (9q34) uye breakpoint cluster region ( BCR) gene paruwoko rurefu rwechromosome 22 (22q11);iyo fusion protein yakavharidzirwa nejini iyi ine tyrosine kinase (TK) chiitiko, uye inomisa nzira dzayo dzekudzika (senge RAS, PI3K, uye JAK / STAT) kukurudzira kupatsanurwa kwesero uye kuvharidzira cell apoptosis, zvichiita kuti masero awedzere zvakashata, uye nekudaro zvichikonzera. kuitika kwe CML.BCR-ABL ndechimwe chezvinhu zvakakosha zvekuongorora zviratidzo zveCML.Shanduko ine simba yedanho rayo rekunyora chiratidzo chakavimbika chekufungidzira kwe leukemia uye inogona kushandiswa kufanotaura kudzoka kweleukemia mushure mekurapwa.

Channel

FAM BCR-ABL fusion gene
VIC/HEX Kudzora Kwemukati

Technical Parameters

Storage Mvura: ≤-18℃ Murima
Sherufu-hupenyu Mvura: 9 mwedzi
Type Type Mienzaniso yemwongo
LoD 1000 Makopi / mL

Zvakananga

 

Iko hakuna kuyambuka-reactivity nemamwe majini efusion TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, uye PML-RARa.
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