Munhu ROS1 Fusion Gene Mutation

ROS1 inonzi transmembrane tyrosine kinase yemhuri ye insulin receptor.ROS1 fusion gene yakasimbiswa seimwe yakakosha isiri-diki cell cancer yemutyairi gene.Semumiriri weimwe yakasarudzika molecular subtype, chiitiko cheROS1 fusion gene muNSCLC Inenge 1% kusvika 2% ROS1 inonyanya kusangana nekugadzirisa magene mumaexons ayo 32, 34, 35 uye 36. Mushure mekunge yasanganiswa nemajini akadai seCD74, EZR, SLC34A2, uye SDC4, icharamba ichimisa ROS1 tyrosine kinase dunhu.Abnormally activated ROS1 kinase inogona kushandura nzira dzekudzika dzepasi dzakaita seRAS/MAPK/ERK, PI3K/Akt/mTOR, uye JAK3/STAT3, nekudaro vachitora chikamu mukuwanda, kusiyanisa uye metastasis yebundu maseru, uye kukonzera cancer.Pakati peROS1 fusion mutations, CD74-ROS1 inosvika 42%, EZR inosvika 15%, SLC34A2 inoita 12%, uye SDC4 inosvika 7%.Zvidzidzo zvakaratidza kuti iyo ATP-inosunga saiti ye catalytic domain yeROS1 kinase uye iyo ATP-inosunga saiti yeALK kinase ine homology inosvika 77%, saka iyo ALK tyrosine kinase diki molecule inhibitor crizotinib zvichingodaro zvine kurapa kuri pachena. mukurapa kweNSCLC nefusion mutation yeROS1.Nokudaro, kuonekwa kweROS1 fusion mutations ndiyo nheyo uye nheyo yekutungamirira kushandiswa kwemishonga yecrizotinib.