Kuchinja kwemajini eROS1 Fusion yeMunhu

ROS1 itransmembrane tyrosine kinase yemumhuri yeinsulin receptor. Ros1 fusion gene yakasimbiswa seimwe gene inokosha isiri diki inokonzeresa kenza yemapapu. Semumiriri wemhando itsva yemamorekuru, kuwanda kweROS1 fusion gene muNSCLC Inenge 1% kusvika 2% ROS1 inonyanya kurongwazve mumajini ayo eexons 32, 34, 35 uye 36. Mushure mekunge yabatanidzwa nemajini akadai seCD74, EZR, SLC34A2, uye SDC4, icharamba ichimutsa ROS1 tyrosine kinase region. ROS1 kinase isingashande zvakanaka inogona kumutsa nzira dzekupa zviratidzo dzakadai seRAS/MAPK/ERK, PI3K/Akt/mTOR, uye JAK3/STAT3, nokudaro ichitora chikamu mukuwanda, kusiyanisa uye kupararira kwemasero egomarara, uye kukonzera kenza. Pakati pekuchinja kweROS1 fusion, CD74-ROS1 inokwana 42%, EZR inokwana 15%, SLC34A2 inokwana 12%, uye SDC4 inokwana 7%. Zvidzidzo zvakaratidza kuti nzvimbo inosunga ATP yenzvimbo inosunga ROS1 kinase uye nzvimbo inosunga ATP yeALK kinase ine homology inosvika 77%, saka ALK tyrosine kinase small molecule inhibitor crizotinib nezvimwewo zvine mhedzisiro inooneka yekurapa mukurapa NSCLC nekuchinja kweROS1. Saka, kuona kuchinja kweROS1 fusion ndiyo hwaro hwekutungamira kushandiswa kwemishonga yecrizotinib.