Human Ros1 Fusion Gene Mutation
Chigadzirwa Zita
HWTS-TM009-Human Ros1 Fusion gen Stution Mutation Kuona Kit (Fluorescence PCR)
Chitupa
CE
Epidemiology
Ros1 idudziro yeTransmembrane muchiase yeInsulin Receptor mhuri. Ros1 Fusion Gene yakasimbiswa seimwe yakakosha isiri-diki cell lung cancer mutyairi mutyairi. Semumiriri wezvitsva zvakasarudzika Subtype, chiitiko cheRos1 genclation inenge 1% kusvika ku2% Ros1 inonyanya kugadzirwa Ezr, SLC33a2, uye SDC4, icharamba ichiita kuti Ros1 Tyrosine Kinase Dunhu. ABNNormy Activated Ros1 kinase inogona kumisikidza yekudzora nzira yekusaina nzira senge ras / Map / Pi3k / erast3 Pakati peRos1 Fusion Vaidzo, CD74-Ros1 maakaundi eanoda 42%, ezr maakaundi e15%, SLC32A2 account, uye SDC4 maakaunti e7%. Zvidzidzo zvakaratidza kuti nzvimbo yeATP yeCatalytic Domain yeRos1 kinase yeAlk Kinase yeChinese Minesky Morizotinib uye saka zvine kujeka mukurapa kweNSCLC neFulion Shanduro yeRos1. Naizvozvo, kuwanikwa kweRos1 fongm majasi ndiyo nzvimbo uye hwaro hwekutungamira kushandiswa kweCrizotinib zvinodhaka.
Chiteshi
| Nhamo | Reaction Buffer 1, 2, 3 ne4 |
| Vic (Hex) | Reaction Buffer 4 |
Technical parameter
| Chengetedza | ≤-18 ℃ |
| Shefu-Hupenyu | 9 mwedzi |
| Type Type | paraffin-yakamedura pathological tishu kana samples samples |
| CV | <5.0% |
| Ct | ≤38 |
| Lod | Iri kit rinogona kuona kupfupika kwemutengo zvakaderera semakopi makumi maviri. |
| Zviridzwa Zvinoshanda: | Yakaiswa Biosystems 7500 chaiyo-nguva PCR systemYakaiswa biosystems 7500 nekukurumidza chaiyo-nguva pcr system Slan ®-96p chaiyo-nguva PCR system Quantstudio ™ 5 chaiyo-nguva pcr systems Lightcycler ®480 chaiyo-nguva PCR system Linegene 9600 Plus Real-Nguva PRR Kuongororwa system Ma-6000 chaiyo-nguva huwandu hweThebrary cyler Biorad cfx96 chaiyo-nguva pcr system Biorad cfx opus 96 chaiyo-nguva pcr system |
Shanda kuyerera
Yakakurudzirwa Reagent Reagent: Rneasy FFPE KIT (73504) Kubva kuQiagen, Paraffin Embedded Tissiction CIT (DP439) Kubva kuTianen Biotech (Beijing) Co, LTD.
