EML HOME4-ALK Fusion genut
Chigadzirwa Zita
HWTS-TM006-Huml EML4-AML FLULEGE Gene Mutation Kuwanikwa Kit (Fluorescence PCR)
Chitupa
TFDA
Epidemiology
Iyi kit inoshandiswa kune yakakodzera kuona gumi nemaviri emhando yemhando yeEML4-ALK Fusion Gumi mumasampuli emunhu asina madiki emapapu emapapu muVitro. Mhedzisiro yebvunzo ndeye clinical referensi chete uye haifanirwe kushandiswa seyega hwaro hwekurapwa kwakasiyana kwevarwere. Vanorembera vanofanira kuita zvakatemerwa kutongwa pane bvunzo dzinoenderana nezvinhu zvakadai semamiriro emurwere, zvinoratidza zvinodhaka, mhinduro dzekurapa, uye zvimwe zviratidzo zveTestiresi. Cancer Cancer ndiyo yakajeka bundu rinozivikanwa pasi rose, uye 80% ~ 85% yezviitiko zvisina-diki cell lung cancer (NSCLC). Gene Kudzidzisa kweEchinoderm Microtuble-Scentublein-(eml4) uye Anaplastic Lymphoma Kinase (ALK) ANSCLERI miriyoni base vaviri. Anosvika makumi maviri emasiyamu akasiyana akawanikwa, pakati peiyo gumi nevaviri vatambi muTafura 1 zvakajairika, apo Mutant 1 (e13) ndiyo inonyanya kuzivikanwa, inoteverwa neAntants 3a uye 3b (e6), accounting yezve 33% uye 29% yevarwere neEML4-ALK Fusion gene gen nsclc, zvichiteerana. ALK inhitors inomiririrwa neCrizotinib madiki-molecule yakatarisana nemishonga yakagadzirirwa yeAlk gegen fusion. Nekurindira basa reALK Tyrosine Kinase Dunhu, richivharira nzvimbo dzayo dzisingaonekwe zvisina masaini. Zvidzidzo zvekiriniki zvakaratidza kuti Crizotinib ane chiyero chinopfuura chinopfuura 61% muvarwere neEML4-ALK FLUSION MUFUNDI, PAMUSORO PENYAYA YEMADZIMAI WEMAHARA. Naizvozvo, kukwezva kweEML4-ALK FUSION MUCHITSAUYO CHINANGWA uye Nheyo dzekutungamira kushandiswa kweCrizotinib zvinodhaka.
Chiteshi
Nhamo | Reaction buffer 1, 2 |
Vic (Hex) | Reaction buffer 2 |
Technical parameter
Chengetedza | ≤-18 ℃ |
Shefu-Hupenyu | 9 mwedzi |
Type Type | paraffin-yakamiswa pathological tishu kana chikamu samples |
CV | <5.0% |
Ct | ≤38 |
Lod | Iri kit rinogona kuona kupfupika kwemutengo zvakaderera semakopi makumi maviri. |
Zviridzwa Zvinoshanda: | Yakaiswa Biosystems 7500 chaiyo-nguva PCR system Yakaiswa biosystems 7500 nekukurumidza chaiyo-nguva pcr system Slan ®-96p chaiyo-nguva PCR system Quantstudio ™ 5 chaiyo-nguva pcr systems Lightcycler ®480 chaiyo-nguva PCR system Linegene 9600 Plus Real-Nguva PRR Kuongororwa system Ma-6000 chaiyo-nguva huwandu hweThebrary cyler Biorad cfx96 chaiyo-nguva pcr system Biorad cfx opus 96 chaiyo-nguva pcr system |
Shanda kuyerera
Yakakurudzirwa Reagent Reagent: Rneasy FFPE KIT (73504) neQiagen, Paraffin-Yakapindirana Tissue Zvikamu Zvakawanda