Kuchinja kwemajini eBCR-ABL eHuman Fusion
Zita rechigadzirwa
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
HWTS-GE016A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR) yakaomeswa nechando nechando.
Epidemiology
Chirwere chemyelogenousleukemia (CML) chirwere chemasero eropa chinouraya. Vanopfuura 95% vevarwere veCML vane Philadelphia chromosome (Ph) mumasero avo eropa. Pathogenesis huru yeCML ndeiyi inotevera: Jini reBCR-ABL fusion rinoumbwa nekuchinjana pakati pe abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) paruoko rurefu rwechromosome 9 (9q34) uye gene reBCR region (BCR) paruoko rurefu rwechromosome 22 (22q11); protein yefusion inonyorwa nejini iri ine tyrosine kinase (TK) activity, uye inomutsa nzira dzayo dzekutumira zviratidzo (dzakadai seRAS, PI3K, uye JAK/STAT) kukurudzira kupatsanurwa kwemasero uye kudzivirira apoptosis yemasero, zvichiita kuti masero awedzere kuipa, uye nokudaro zvichikonzera kuitika kweCML. BCR-ABL chimwe chezviratidzo zvakakosha zvekuongorora CML. Kuchinja kwehuwandu hwezviratidzo zvechirwere ichi chiratidzo chakavimbika chekuongorora chirwere cheleukemia uye chinogona kushandiswa kufanotaura kudzoka kwechirwere cheleukemia mushure mekurapwa.
Chiteshi
| FAM | Jini reBCR-ABL rekusanganiswa |
| VIC/HEX | Kudzora Kwemukati |
Magadzirirwo ehunyanzvi
| Kuchengetera | Mvura: ≤-18℃ murima |
| Nguva yekuzorora | Mvura: mwedzi 9 |
| Rudzi rwemuenzaniso | Mienzaniso yemwongo wemapfupa |
| LoD | Makopi 1000/mL |
| Kunyatsojeka
| Hapana kusangana kwemakemikari nemamwe majini ekubatanidza TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, uye PML-RARa |
| Zvishandiso Zvinoshanda | Maitiro Ekushandisa Ezvinhu Zvehupenyu 7500 Masisitimu EPCR Enguva Yechokwadi Maitiro eApplied Biosystems 7500 PCR Systems Inokurumidza Munguva Yechokwadi Masisitimu ePCR eQuantStudio® 5 Enguva Yechokwadi Masisitimu ePCR eSLAN-96P Enguva Yechokwadi Sisitimu yePCR yeLightCycler®480 Yenguva Yechokwadi Sisitimu yeKuona PCR yeLineGene 9600 Plus Yenguva Yechokwadi MA-6000 Chaiyo-Nguva Yekuyera Kupisa Kwemhepo Sisitimu yePCR yeBioRad CFX96 Yenguva Yechokwadi Sisitimu yePCR yeBioRad CFX Opus 96 Yenguva Yechokwadi |
