Munhu BCR-ABL Fusion Gene Mutation
Product name
HWTS-GE010A-Munhu BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
HWTS-GE016A-Freeze-yakaomeswa Munhu BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Epidemiology
Chronic myelogenousleukemia (CML) chirwere chakashata chechirwere chehematopoietic stem masero. Vanopfuura 95% yevarwere veCML vanotakura Philadelphia chromosome (Ph) mumasero avo eropa. Chirwere cheCML chinonyanyozivikanwa seizvi: BCR-ABL fusion gene inoumbwa nekuchinjika pakati peabl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) paruoko rurefu rwechromosome 9 (9q34) uye breakpoint cluster region (BCR2q21 gene) ; iyo fusion protein yakavharidzirwa nejini iri ine tyrosine kinase (TK) chiitiko, uye inomutsa nzira dzayo dzepasi (dzakadai seRAS, PI3K, uye JAK/STAT) kukurudzira kupatsanurwa kwesero uye kuvharidzira cell apoptosis, zvichiita kuti masero awedzere zvakashata, uye nekudaro zvichikonzera kuitika kweCML. BCR-ABL ndechimwe chezvinhu zvakakosha zvekuongorora zviratidzo zveCML. Shanduko ine simba yedanho rayo rekunyora chiratidzo chakavimbika chekufungidzira kwe leukemia uye inogona kushandiswa kufanotaura kudzoka kweleukemia mushure mekurapwa.
Channel
| FAM | BCR-ABL fusion gene |
| VIC/HEX | Kudzora Kwemukati |
Technical Parameters
| Storage | Mvura: ≤-18℃ Murima |
| Sherufu-hupenyu | Mvura: 9 mwedzi |
| Type Type | Mienzaniso yemwongo |
| LoD | 1000 Makopi / mL |
| Zvakananga
| Iko hakuna kuyambuka-reactivity nemamwe majini efusion TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, uye PML-RARa. |
| Zvishandiso Zvishandiso | Applied Biosystems 7500 Chaiyo-Nguva PCR Systems Applied Biosystems 7500 Fast Real-Time PCR Systems QuantStudio® 5 Chaiyo-Nguva PCR Systems SLAN-96P Chaiyo-Nguva PCR Systems LightCycler®480 Chaiyo-Nguva PCR system LineGene 9600 Plus Chaiyo-Nguva PCR Detection System MA-6000 Chaiyo-Nguva Quantitative Thermal Cycler BioRad CFX96 Chaiyo-Nguva PCR System BioRad CFX Opus 96 Chaiyo-Nguva PCR System |
