Human BCR-AbL Fusion gener mutation
Chigadzirwa Zita
HWTS-GE010A-Human BCR-AbL Fusion Gene Mutation Kuona Kit (Fluorescence PCR)
HWTS-GE016A-Hure-Darze-Yakaomeswa Humunhu BCR-Abl Fusion Gene Mutation Kuwanikwa Kit (Fluorescence PCR)
Epidemiology
Chirwere chenguva isingaperi (cml) chirwere chakaipisisa chechirwere chegomatipoetic stem cell. Anopfuura 95% yeCML varwere vanotakura iyo Philadelphia chromosome (phi) mumasero eropa. Pretominant Pathogeneis yeCML iri: Iyo BCR-ABL Fiusion yakaumbwa neAbl Porto-OnLogene Homolog 1 (9Q34) uye iyo Breakpoint Curuster Dunhu ( Bcr) gene kurudyi ruoko rwe chromosome 22 (22q11); Iyo protein yeFusion yakavapo neiyo Gume ine Tyrosine Kinase (TK) chiitiko charo chekusarudzika, pi3k) kusekwa Apoptosis, kuita masero anowedzera zvinokuvadza, uye nekudaro zvichikonzera kuitika kwe cml. Bcr-abl ndeimwe yeiyo yakakosha yekuongorora zviratidzo zve cml. The dynamic change of its transcript level is a reliable indicator for prognostic judgment of leukemia and can be used to predict the recurrence of leukemia after treatment.
Chiteshi
| Nhamo | Bcr-abl fusion gene |
| Vic / Hex | Kutonga kwemukati |
Technical parameter
| Chengetedza | Mvura: ≤-18 ℃ murima |
| Shefu-Hupenyu | Mvura: 9 mwedzi |
| Type Type | Pfupa remombe samples |
| Lod | 1000 makopi / ml |
| Chokwadi
| Iko hakuna kuyambuka-chiitiko nedzimwe fiusi yejini yechigadzirwa tel-aml1, e2a-pbx1, mll-af4, aml1-eto, uye pml-rara |
| Zviridzwa zvinoshanda | Yakaiswa Biosystems 7500 chaiyo-nguva PCR system Yakaiswa biosystems 7500 nekukurumidza chaiyo-nguva pcr system Quantstudio® 5 chaiyo-nguva pcr system Slan-96p chaiyo-nguva pcr system Lightcycler ®480 chaiyo-nguva PCR system Linegene 9600 Plus Real-Nguva PRR Kuongororwa system Ma-6000 chaiyo-nguva huwandu hweThebrary cyler Biorad cfx96 chaiyo-nguva pcr system Biorad cfx opus 96 chaiyo-nguva pcr system |
