Gomarara remapapu richiri chimwe chezvikonzero zvikuru zverufu rwakakonzerwa nekenza pasi rose, pamwe nekenza yemapapu isiri masero madiki (NSCLC)zvichireva zvinopfuura80%yezvirwere zvese zvegomarara remapapu. Muna 2020 chete, vanhu vanopfuuraMamiriyoni 2.2Nyaya itsva dzekenza yemapapu dzakaonekwa pasi rose

Sezvo kenza yemhando yepamusoro ichiramba ichichinja manejimendi yeNSCLC,Kuongororwa kwekuchinja kwemasero eEGFR kwave chinhu chinokosha pakurapa kwakarurama.Kushanda kwekuchinja kwemuviri muChinopa kukura kweganda (EGFR)Magene ari pakati pezviratidzo zvinonyanya kushanda mukurapa muNSCLC, zvichigonesa kusarudzwa kwemishonga yakanangwa iyo inovandudza zvakanyanya mhedzisiro yekiriniki muvarwere vanokodzera.

Zvichienzaniswa ne chemotherapy yakajairika,EGFR tyrosine kinase inhibitors (TKIs)kudzivirira nzira dzisina kujairika dzekuratidza zviratidzo zveEGFR dzinoita kuti bundu rikure uye rirambe richikura, zvichipa kushanda kwakanaka uye kuchengetedzeka kwakanaka kune varwere vane EGFR-mutated NSCLC. Saka kuziva kwakarurama uye panguva yakakodzera shanduko dzeEGFR kwakakosha pakusarudza kurapwa kwekutanga kwakakodzera uye kutsigira sarudzo dzekurapa dzinotevera sezvo kuramba kwechirwere kuchikura.

Zvinonyanya Kukosha zveGwaro

Mitemo yepamusoro yekiriniki yepasi rose inogara ichisimbisa kukosha kwekuongororwa kwakazara kwe biomarker muvarwere vane NSCLC yepamusoro.

NCCN Clinical Practice Guidelines muOncology

-Kurudzira kuongororwa kwakazara kwemamorekuru usati watanga kurapwa kwakanangana nekutanga kuvarwere vane NSCLC yepamusoro kana kuti yakapararira.

-Kuchinja kweEGFR kwakakosha pakusarudza nzira dzekurapa dzakakodzera.

ESMO Clinical Practice Guideline

Inokurudzira bvunzo dzenguva dzose dzeKuchinja kweEGFR mu exons 18–21kuona varwere vakakodzera kurapwa kwakanangana neEGFR.

Mazano aya anoratidza basa guru rekuongororwa kwekuchinja kweEGFR nenzira yakarurama, inonzwisisika, uye panguva yakakodzera mukubatsira varwere vane NSCLC kurapwa nemazvo.

Kiti yeKuona Kuchinja kweGene 29 yeHuman EGFR (Fluorescence PCR)-Kuongororwa Kwakarurama Kwesarudzo Dzekurapa Dzine Chivimbo

Macro & Micro-Test'sKiti yeKuona Kuchinja kweGene 29 yeHuman EGFR (Fluorescence PCR)inobvumira kuonekwa kwezvirwere nekukurumidza uye nemazvo29 kushanduka kweEGFR kwakakosha mukirinikimhirimaexon 18–21, vachitsigira sarudzo dzekurapa dzakarurama mukati merwendo rwese rwemurwere.

Muedzo uyu unoona zvese zviri zvivirishanduko dzinokonzera kushushikana kwemishonga uye dzinokonzerwa nekusagona kurapwa, zvichibatsira vanachiremba kuziva varwere vanogona kubatsirwa nemishonga inotarirwa neEGFR yakaita segefitinibuyeosimertinib, ukuwo vachitsigira kuita sarudzo dzekurapa munguva yese yekurapwa.

Sei Uchifanira Kusarudza Macro & Micro-Test's EGFR Testing Kit?

Kufukidzwa Kwakazara Kwekuchinja Kwemuviri

• · Inoongorora29 shanduko dzeEGFR dzakakosha pakurapamhiri kwemaexons18–21
• · Inofukidza zvese zviri zvivirikunzwa kwezvinodhakauyeine chekuita nekurambashanduko dzemuviri
• · Tekinoroji yeARMS Yakavandudzwaine patent enhancer yekuvandudza hunyanzvi hwayo
• · Kuwedzerwa kweEnzymaticinoderedza mamiriro ekumashure emusango uye inovandudza kunyatsoonekwa kwedata
• · Tekinoroji Yekudzivirira Kupisainoderedza kuwedzera kusina kuenzana uye inowedzera hunyanzvi hwayo
• · Inoona shanduko dzemuviri ne1% mutant allele frequency
• · Mhedzisiro yezvinangwa mukati memaminitsi zana nemakumi maviri
• · Kudzora kwemukati uyeUNG enzymekuderedza mhedzisiro yenhema
• · Inotsigira zvesetishu, plasma kana serumamples
• · Inoenderana nemidziyo yePCR yenguva chaiyo
• · Nguva yekushanda kwemwedzi gumi nemiviri

Tekinoroji Yekuongorora Yepamusoro

Kushanda Kwepamusoro Kwekuongorora

Kufamba Kwebasa Kunochinjika

Kurapa Kunotungamirira Nechivimbo

Kuongororwa kwekuchinja kweEGFR kwakavimbika kunogonesa vanachiremba kuita sarudzo dzekurapa vane ruzivo kubva pakutanga kuongororwa kuburikidza nekutarisa kusawirirana kwechirwere.

Kuongororwa kamwe chete. Kufukidzwa kwakakwana kwekuchinja kwemuviri. Kuvimba kukuru mukuita sarudzo dzekiriniki.

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