Kuchinja C. Kuona Kusiyana: Kuwana Kuongororwa Kwemamorekuru Kwakakwana, Kunogona Kuitwa Otomatiki, Muenzaniso-Kubva-Kupindura

Chii chinokonzera chirwere cheC. Diff?

1. Utachiona hweDiff hunokonzerwa nebhakitiriya rinozivikanwa seClostridioides difficile (C. difficile), iro rinowanzogara muura risingakuvadzi. Zvisinei, kana hutachiona hwemudumbu hukakanganiswa, kazhinji kushandisa mishonga inorwisa mabhakitiriya yakawanda,C. zvakaomazvinogona kukura zvakanyanya uye kugadzira chepfu, zvichikonzera hutachiona.

Utachiona uhwu huripo mumhando mbiri dzinokonzera huturu nedzisina huturu, asi mhando dzehuturu (toxins A naB) ndidzo chete dzinokonzera chirwere. Dzinokonzera kuzvimba nekukanganisa masero emudumbu. Toxin A inonyanya kukuvadza ura, ichiwedzera kupinda kwemvura, uye inokwezva masero ekudzivirira muviri anoburitsa ma cytokines anokonzera kuzvimba. Toxin B, cytotoxin ine simba, inotarisa actin cytoskeleton yemasero, zvichikonzera kutenderera kwemasero, kubviswa, uye pakupedzisira kufa kwemasero. Pamwe chete, huturu uhu hunokonzera kukuvara kwematishu uye mhinduro yakasimba yekudzivirira muviri, iyo inoratidzwa se colitis, manyoka, uye mune zviitiko zvakakomba, pseudomembranous colitis—kuzvimba kwakakomba kweura.

C. Diff inopararira sei?

1. Kupararira kwechirwere ichi kuri nyore. Chinowanikwa muzvipatara, chinowanzo kuwanikwa muICU, mumaoko evashandi vechipatara, pasi pezvipatara uye pamaoko, pama thermometers emagetsi, nemimwe michina yekurapa…

Zvinhu Zvinokonzera Njodzi dzeC. Diff Infection

• Kugara muchipatara kwenguva refu;
• Kurapa kwehutachiona;
• mishonga yekurapa nemakemikari;
• Kuvhiyiwa kwazvino (maoko emudumbu,nzira yekubvisa gastric, kuvhiyiwa kweura hukuru);
• Kudya kunovaka muviri mudumbu;
• Utachiona hweC. diff husati hwatanga;

Zviratidzo zvehutachiona hweC. Diff

Chirwere cheC. diff chinogona kusafadza. Vanhu vazhinji vanorwara nemanyoka uye kusagadzikana mudumbu. Zviratidzo zvinonyanya kuzivikanwa ndeizvi:manyoka, kurwadziwa mudumbu, kuda kurutsa, kurasikirwa nechido chekudya, fivha.

Sezvo hutachiona hweC. diff huchiwedzera kuipa, pachava nekukura kwerudzi rwakaomarara rweC. diff runozivikanwa secolitis, pseudomembrane enteritis uye kunyange rufu.

Kuongororwa kweC. Diff Infection

Tsika yeMabhakitiriya: Inonzwa asizvinotora nguva (mazuva 2-5), haigoni kusiyanisamhando dzezvirwere zvinokonzeresa chepfu uye zvisina chepfu;

Tsika yeToxin:inoona mhando dzezvirwere zvinokonzera chepfu dzinokonzera chirwere asi dzinotora nguva (mazuva 3-5) uye dzisinganyanyi kubatwa nechirwere;

Kuonekwa kweGDH:inokurumidza (1-2hrs) uye inodhura zvishoma, inononoka zvikuru asi haigone kusiyanisa mhando dzezvirwere zvinokonzera chepfu nedzisina chepfu;

Kuyedzwa kweCytotoxicity Neutralization Assay (CCNA):Inoona chepfu A neB ine hunhu hwakanyanya asi inotora nguva (mazuva maviri kusvika matatu), uye inoda nzvimbo dzakanyatsogadzirwa nevashandi vakadzidziswa;

Toxin A/B ELISA: Bvunzo iri nyore uye inokurumidza (1-2hrs) ine kusanzwisisika kwakaderera uye zviratidzo zvenhema zvinowanzoonekwa;

Miedzo yeNucleic Acid Amplification (NAATs): Inokurumidza (1-3hrs) uye inonyanya kunzwa uye yakananga, ichiona majini anokonzera kugadzirwa kwechepfu;

Pamusoro pezvo, bvunzo dzekuongorora ura, dzakadai seKuongororwa kweCTuyeX-rays, inogona kushandiswawo kubatsira mukuongorora C. diff uye matambudziko eC. diff, akadai secolitis.

Kurapa kwehutachiona hweC. Diff

Kune nzira dzakawanda dzekurapa hutachiona hweC. diff. Heano mamwe masarudzo akanakisa:

• Mishonga inorwisa mabhakitiriya inonwiwa senge vancomycin, metronidazole kana fidaxomicin inowanzo shandiswa sezvo mushonga unogona kupfuura nemudumbu wosvika muura hunogara mabhakitiriya eC. diff.
• Metronidazole inopinzwa mutsinga inogona kushandiswa kurapa kana hutachiona hweC. diff hwakanyanya.
• Kuisirwa kwe microbiota kubva mutsvina kwakaratidza kushanda zvakanaka mukurapa hutachiona hweC. diff hunowanzoitika uye hutachiona hweC. diff hwakakomba husingapindure nemishonga inorwisa mabhakitiriya.
• Kuvhiyiwa kunogona kudiwa kana paine chirwere chakanyanya.

Itsva dmhinduro yekuongorora kubva kuMMT

Mukupindura kudiwa kwekukurumidza uye kwakarurama kwekuona C. difficile, tinopa Nucleic Acid Detection Kit yedu itsva yeClostridium difficile toxin A/B gene, tichipa simba kune vashandi vehutano kuti vaongorore nekukurumidza uye nemazvo uye kutsigira kurwisa hutachiona hunowanikwa muchipatara.

• Kunzwa Kwakanyanya: Inoona yakaderera se200 CFU/mL,;
• Kunangwa Kwakarurama: Anonyatso tsanangura C. zvakaomajini reA/B rechepfu, kuderedza zviratidzo zvenhema;
• Kuonekwa Kwehutachiona Hwakananga: Inoshandisa nucleic acid testing kuti ione zvakananga majini etoxin, zvichigadzira mwero wepamusoro wekuongorora.
• Inoenderana zvizere nezvishandiso zvePCR zvinobata ma laboratori akawanda;

Mhinduro yeMhinduro yeMhinduro iri paMacro & Micro-Test'sAIO800Rabhoritari yePCR yeNharembozha

Kugadzira Sample-to-Answer Automation – Isa machubhu ekutanga emuenzaniso (1.5–12 mL) zvakananga, uchibvisa mapaipi emaoko. Kubvisa, kuwedzera, uye kuona zvinhu zvinongoerekana zvaitika, zvichideredza nguva yekushanda uye kukanganisa kwevanhu.

• Dziviriro yeKusvibiswa kweMatanho 11 - Kufamba kwemhepo nenzira, kumanikidzwa kusina kunaka, kusefa kweHEPA, kucheneswa kweUV, maitiro akavharwa, nezvimwe zvinodzivirira zvakabatana zvinodzivirira vashandi uye zvinovimbisa mhedzisiro yakavimbika panguva yekuedzwa kwepamusoro-soro.

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