Kuonekwa kwetatu-mu-imwe nucleic acid: COVID-19, furuwenza A uye hutachiona hwefuruwenza B, zvese muchubhu imwe!

Covid-19 (2019-nCoV) yakonzera mazana emamiriyoni ehutachiona uye mamirioni ekufa kubva payakatanga mukupera kwa2019, zvichiita kuti ive yehutano hwepasi rose.World Health Organisation (WHO) yakaisa pamberi mashanu "mutant strains zvekunetsekana"[1], zvinoti Alpha, Beta, Gamma, Delta neOmicron, uye Omicron mutant strain ndiyo iri kunetsa mudenda repasi rose parizvino.Mushure mekutapukirwa neOmicron mutant, zviratidzo zvacho zvakapfava, asi kune vanhu vakasarudzika senge vanhu vasina hutachiona, vakwegura, zvirwere zvisingaperi uye vana, njodzi yekurwara zvakanyanya kana kufa mushure mekutapukirwa ichiri yakakwira.Mhosva yekufa kwehuwandu hwemutant strains muOmicron, data yepasirese inoratidza kuti avhareji yekufa kwekesi inenge 0.75%, inova kanomwe kusvika kasere kune efuruwenza, uye nhamba yekufa kwevanhu vakura, kunyanya avo vanopfuura makore makumi masere. yekare, inodarika 10%, inova kanenge ka100 iyo yefuruwenza[2].Makiriniki akajairika ehutachiona ndeyefivha, kukosora, kuoma kwehuro, kurwadziwa kwehuro, myalgia, nezvimwewo. Varwere vakanyanya vanogona kunge vane dyspnea uye / kana hypoxemia.

Kune marudzi mana emavhairasi efuruwenza: A, B, C uye D. Marudzi makuru edenda ari subtype A (H1N1) neH3N2, uye strain B (Victoria neYamagata).Influenza inokonzerwa nehutachiona hwefuruwenza inokonzeresa mwaka nedenda risingafungidzike gore rega rega, nehuwandu hwezviitiko.Maererano nehuwandu, mamiriyoni 3.4 emakesi anorapwa zvirwere zvefuruwenza gore negore[3], uye dzinenge 88,100 zviitiko zvefuruwenza-zvine hukama hwekufema zvirwere zvinotungamira kurufu, zvichiverengera 8.2% yezvirwere zvekufema kufa.[4].Zviratidzo zvekiriniki zvinosanganisira fivha, kutemwa nemusoro, myalgia uye chikosoro chakaoma.Mapoka ane njodzi huru, akadai sevakadzi vane pamuviri, vacheche, vakwegura uye varwere vane zvirwere zvisingaperi, vanowanzobatwa nemabayo nemamwe matambudziko, izvo zvinogona kutungamirira kurufu mumatambudziko akaoma.

1 COVID-19 ine njodzi dzefuruwenza.

Co-infection yefuruwenza neCOVID-19 inogona kuwedzera kukanganisa kwechirwere.Ongororo yeBritain inoratidza izvozvo[5], zvichienzaniswa nehutachiona hweCCIDID-19 chete, njodzi yekufefeterwa kwemagetsi uye njodzi yekufa muchipatara muCOVID-19 varwere vane hutachiona hwefuruwenza yakawedzera ne4.14 nguva uye 2.35 nguva.

Tongji Medical College yeHuazhong University of Science and Technology yakaburitsa chidzidzo[6], izvo zvaisanganisira zvidzidzo makumi mapfumbamwe neshanu zvinosanganisira varwere makumi matanhatu nenomwe nemazana manomwe nenomwe muCOVID-19.Huwandu hwekupararira kwehutachiona hwefuruwenza hwakabatana hwaive 2.45%, pakati peiyo furuwenza A yakaverengera chikamu chepamusoro.Kuenzaniswa nevarwere vanongotapukirwa neCCIDID-19, varwere vakatapukirwa nefuruwenza A vane njodzi yakanyanya yezvakakomba, kusanganisira kubvumidzwa neICU, kutsigira kwemagetsi kufefetera uye kufa.Kunyange zvazvo kuwanda kwe-co-infection kwakaderera, varwere vane co-infection vanotarisana nenjodzi yakakura yemigumisiro yakakomba.

Meta-analysis inoratidza izvozvo[7], kana ichienzaniswa neB-rukova, A-rukova inonyanya kutapukirwa neCOVID-19.Pakati pevarwere zana nemakumi mana nevatatu vakabatwa nechirwere ichi, 74% vanobatwa neA-stream, uye 20% vanobatwa neB-stream.Co-infection inogona kukonzera kurwara kwakanyanya kwevarwere, kunyanya pakati pemapoka anotambura sevana.

Tsvagiridzo yevana nevechiri kuyaruka vari pasi pemakore gumi nemasere vakaiswa muchipatara kana kufa nefuruwenza panguva yefuruwenza muUnited States muna 2021-2022 yakawanikwa.[8]kuti chiitiko chekubatana-utachiona nefuruwenza muCOVID-19 chinofanirwa kutariswa.Pakati penyaya dzine chekuita nefuruwenza muchipatara, 6% vakatapukirwa neCCIDID-19 nefuruwenza, uye chikamu cherufu chine chekuita nefuruwenza chakakwira kusvika pagumi nematanhatu%.Tsvakiridzo iyi inoratidza kuti varwere vane hutachiona hweCCIDID-19 nefuruwenza vanoda rubatsiro rwekufema uye rusingapindike kupfuura avo vanongobatwa nefuruwenza, uye vanoti kutapurirana pamwe chete kunogona kukonzera njodzi yechirwere muvana. .

2 Yakasiyana kuongororwa kwefuruwenza uye COVID-19.

Zvose zvirwere zvitsva uye furuwenza zvinopararira, uye kune kufanana mune zvimwe zviratidzo zvekiriniki, zvakadai sefivha, chikosoro uye myalgia.Zvisinei, zvirongwa zvekurapa mavhairasi maviri aya zvakasiyana, uye mishonga inorwisa utachiona inoshandiswa yakasiyana.Munguva yekurapa, zvinodhaka zvinogona kushandura maitiro emakiriniki echirwere, zvichiita kuti zvive zvakaoma kuongorora chirwere chete nezviratidzo.Naizvozvo, kuongororwa kwakaringana kweCCIDID-19 uye furuwenza inofanirwa kuvimba nekuonekwa kwehutachiona kuti ive nechokwadi chekuti varwere vanogona kuwana kurapwa kwakakodzera uye kunoshanda.

Mazano akati wandei ekubvumirana pakuongorora uye kurapwa anoratidza kuti kunyatsozivikanwa kweCCIDID-19 uye hutachiona hwefuruwenza kuburikidza nekuongororwa murabhoritari kwakakosha pakugadzira chirongwa chekurapa chine musoro.

《Influenza Diagnosis uye Kurapa Chirongwa (2020 Edition)[9]uye 《Kuongororwa kwefuruwenza yevakuru uye Kurapwa Standard Emergency Expert Consensus (2022 Edition)[10]zvese zvinojekesa kuti furuwenza yakafanana nezvimwe zvirwere muCCIDID-19, uye COVID-19 ine zvinyoro uye zvakajairika zviratidzo zvakaita sefivha, kukosora kwakaoma uye kurwadziwa kwehuro, izvo zvisiri nyore kusiyanisa nefuruwenza;Kuratidzira kwakanyanya uye kwakakomba kunosanganisira mabayo akanyanya, acute respiratory distress syndrome uye kusashanda kwenhengo, izvo zvakafanana nekuratidzwa kwekiriniki kwefuruwenza yakaoma uye yakaoma, uye inoda kusiyaniswa neiyo etiology.

《novel coronavirus chirwere chekuongorora uye chirongwa chekurapa (yegumi edition yekuitwa kwekuedza》[11]akataura kuti hutachiona hweCovid-19 hunofanirwa kusiyaniswa kubva kuhutachiona hwepamusoro hwekufema hunokonzerwa nehumwe hutachiona.

3 Misiyano yekurapa furuwenza uye hutachiona hweCOVID-19

2019-nCoV uye furuwenza zvirwere zvakasiyana zvinokonzerwa nemavhairasi akasiyana, uye nzira dzekurapa dzakasiyana.Kushandiswa kwakakodzera kwemishonga inorwisa mavhairasi kunogona kuvharidzira matambudziko akakomba uye njodzi yekufa kwezvirwere zviviri izvi.

Zvinokurudzirwa kushandisa madiki mamorekuru antiviral zvinodhaka akadai seNimatvir/Ritonavir, Azvudine, Monola uye neutralizing antibody zvinodhaka zvakaita seAmbaviruzumab/Romisvir monoclonal antibody jekiseni muCOVID-19.[12].

Mishonga inorwisa furuwenza inonyanya kushandisa neuraminidase inhibitors (oseltamivir, zanamivir), hemagglutinin inhibitors (Abidor) uye RNA polymerase inhibitors (Mabaloxavir), ine migumisiro yakanaka pahutachiwana hwefuruwenza A neB hwakakurumbira huripo iye zvino.[13].

Kusarudza yakakodzera antiviral regimen kwakakosha kwazvo pakurapa kwe2019-nCoV uye furuwenza.Nokudaro, zvakakosha zvikuru kuziva pathogen zvakajeka kutungamirira mishonga yekiriniki.

4 COVID-19/ Furuwenza A / Furuwenza B katatu majoini ekuongorora nucleic acid zvigadzirwa

Ichi chigadzirwa chinopa nekukurumidza uye kwakaringana kuzivikanwa of 2019-nCoV, furuwenza A uye mavhairasi efuruwenza B, uye inobatsira kusiyanisa 2019-nCoV nefuruwenza, zvirwere zviviri zvekufema zvinotapukira zvine zviratidzo zvekiriniki zvakafanana asi nzira dzekurapa dzakasiyana.Nekuziva pathogen, inogona kutungamira kuvandudzwa kwekiriniki yezvirongwa zvekurapa zvakanangwa uye kuona kuti varwere vanogona kuwana kurapwa kwakakodzera munguva.

Total solution:

Sample muunganidzwa--Nucleic acid kudhirowa--Detection reagent--polymerase chain reaction