-Kuchinja Kuongorora Njodzi NeTiered Multiplex Diagnostic Portfolio muKuenderana neNhungamiro dzeWHO dza2025–2026
1.Iceberg iri pasi pevhu
Vhiki rino,Kubvumbi 12–18, 2026, inocherechedza Vhiki reKuziva Nezvezvirwere Zvepabonde. Dingindira revhiki rino rinoshanda sechiyeuchidzo chakasimba: mutoro wepasi rose wezvirwere zvepabonde (STIs) uchiri kuderedzwa zvakanyanya. Sekureva kwefungidziro yeWorld Health Organization (WHO), kunevanhu vanopfuura miriyoni imwe chete vane zvirwere zveSTI zvinorapika zuva rega regapakati pevanhu vane makore 15-49, zvichireva kuti vanhu vanosvika mamiriyoni 374 vanobatwa nechirwere ichi gore rega rega. Zvisinei, huwandu hwese hwezvirwere zvinotapukira zvinopararira kupfuura hutachiona huna hunorapika (chlamydia, gonorrhoea, syphilis, uye trichomoniasis). Hunosanganisira mabhakitiriya akasiyana-siyana (semuenzaniso, Mycoplasma genitalium, Ureaplasma species, Gardnerella vaginalis, Group B Streptococcus), mavhairasi (herpes simplex virus types 1 and 2), protozoa (Trichomonas vaginalis), uye fungi (Candida species) - mazhinji acho haawanikwe mumaitiro echinyakare ekuongorora syndromic kana single-pathogen.
Kusavanza kwehutachiona husina zviratidzo kuchiri dambudziko guru mukutonga njovhera pasi rose. Utachiona uhwu hunongoerekana hwava chirwere chinozvimba muchiuno, pamuviri usina kubuda, kusabereka, uye migumisiro yakaipa yekuzvimba, asiwo hunoshanda senzvimbo dzinotapurirana dzinogara dziripo, zvichikurudzira kubuda kwekusagona kurwisa utachiona - kunyanya N. gonorrhoeae, iyo ceftriaxone yava sarudzo yekupedzisira inoshanda munyika dzakawanda.
Zvichienderana neizvi, WHO yakaburitsa muna Chikunguru 2025 mamodule maviri enhungamiro akavakirwa pauchapupu:Nhungamiro dzeKutarisira Utachiona Husina Zviratidzo Zvepabonde[1] uyeMazano ekupa mabasa ehutano ekudzivirira nekutarisira zvirwere zvepabonde[2]. Izvi zvakateverwa muna Kukadzi 2026 neBhuku reWHO rakabatanidzwa rekushandisa pazvirwere zvepabonde[3], iyo inobatanidza gwara rese riripo rekudzivirira nekutarisira zvirwere zvepabonde. Pamusoro pezvo,Pfupiso yezvakataurwa neWHO pamusoro pekuongororwa kweHIV nehutachiona hwepabonde, kudzivirira, kurapwa, kutarisirwa uye kupa masevhisi[4] inopa musanganiswa wakakwana wenhungamiro iripo. Pamwe chete, magwaro aya anoratidza gwara rakajeka:kuwedzera kuongororwa kweSTI kwakavakirwa pa nucleic acid amplification test (NAAT), kunyanya pakati pevanhu vasina zviratidzo, uye kushandisa nzira dzekuedza dzinoshanda zviri nyore, dziri nyore kuwana, uye dzakabatana.— kusanganisira bvunzo dze multiplex dzinofukidza hutachiona hwakasiyana-siyana muongororo imwe chete.
Chinyorwa chino chinovaka pamusoro peScience multiplex molecular diagnostic portfolio yeMacro & Micro-Test Biotech Co., Ltd., yakabatana negwara razvino reWHO rakavakirwa pauchapupu. Chinopa nzira yekuyedza yakarongwa - kubvakuongororwa kwechinangwa chimwe chete, bvunzo dze triplex, 9-plex, 14-plex, kusvika 18-plex— uye inoratidza kuti nzira dzakanyatsojeka, dzinochinjika, uye dzinoshanda dzinogona sei kugadzirisa zvinodiwa pakuongorora zvirwere zvepabonde zvisina zviratidzo mumamiriro akasiyana ekurapa.
1.Humbowo Hukuru kubva kuNhungamiro dzeWHO dzemazuva ano uye Zvazvinoreva paTekinoroji yeKuongorora
2.1 Mazano Anobva Pauchapupu Hwekuongorora Njodzi Dzisina Zviratidzo
IyoNhungamiro dzeKutarisira Utachiona Husina Zviratidzo Zvepabonde(Chikunguru 2025)[1], yakagadzirwa uchishandisa nzira yeGRADE ine ongororo dzakarongeka uye ongororo dzenyanzvi, inotarisa zvakanyanya pamazano ane humbowo hwekuongorora N. gonorrhoeae neC. trachomatis. Mirayiridzo iyi inokurudzira zvakajeka kuongororwa kwakanangana nevanhu vakakosha uko kune zviwanikwa zviripo, kusanganisiravakadzi vane pamuviri, vechidiki vari kuita zvepabonde nevechidiki vane makore ari pakati pe10–24, vashandi vepabonde, nevarume vanoita zvepabonde nevarume (MSM)Zvinokurudzirwa kuti zviongororwe kakawanda seikuongororwa kwegore negore kwevanhu vanoita zvepabonde nevanhu vanosvuta, kana mwedzi mitanhatu yega yegauko zvinogoneka.
Kuburitswa kwenhungamiro idzi kunoratidza shanduko huru muhurongwa hwepasi rose hweSTI — kubva pa "kutungamirirwa nezviratidzo" kuenda ku "kuongorora zviri kushanda." Sezvakataurwa naDr Meg Doherty, Mutungamiriri weWHO's Global HIV, Hepatitis and STIs Programs, kuti: "Mazano matsva aya anovavarira kuvhara mikaha iri kuramba iripo yemitemo uye yebasa, kunyanya kune STI dzisina zviratidzo, uye kubatsira nyika kuti dzifambe nekukurumidza kusvika kuzvinangwa zva2030"[1].
2.2 Kubatanidzwa Kwebasa uye Kubvumirana Kwepasi Pose paKuedza kweMultiplex
Yakaburitswa panguva imwe cheteMazano ekupa mabasa ehutano ekudzivirira nekutarisira zvirwere zvepabonde(Chikunguru 2025)[2] inokurudzira mabasa ehutano anotarisana nevanhu kuburikidza nezvikamu zvina:kuparadzanisa nharaunda, kubatanidzwa, kugovana mabasa, uye hutano hwedhijitariZvinoshamisa kuti, munaGunyana 2025, WHO yakazivisa kuumbwa kweGwaro Rekuvandudza Gwaro rekuvandudzanhungamiro dzepasi rose dzekutanga dzakavakirwa pauchapupu pakuongorora multiplex, kunyanya kutarisa HIV, hepatitis yehutachiona, uye STIs[5]. WHO inotsanangura kuongororwa kwemultiplex se "nzira inoshandisa sample imwe chete uye assay imwe chete kana platform yekuona hutachiona hwakawanda panguva imwe chete" uye inotaura kuti "inzira ine tariro yekuvandudza kushanda zvakanaka, kuwedzera kuongororwa kwezvirwere, uye kuwedzera kushanda zvakanaka kwemari"[5].
Izvi zvinoratidza kutimultiplex NAAT yashanduka kubva pakushandisa nzira yekurabhoritari kuita chishandiso chikuru chehurongwa hwepasi rose hwehutano hwevanhuMunzvimbo dzisina zviwanikwa zvakawanda, kushandisa imwe chete, kuongorora hutachiona hwakawanda kunovandudza zvikuru mukana wekuyedzwa uye kushanda zvakanaka kwemari -- kunyanya zvakakodzera kuongororwa kwakakura kwevanhu vasina zviratidzo uye kugara vachiongororwa mapoka ane njodzi huru.
2.3 Bhuku re2026 Consolidated Operational Handbook: Chirongwa Chekuongorora Multiplex
Bhuku reWHO Consolidated Operational Handbook pamusoro pezvirwere zvepabonde (Kukadzi 2026)[3] rinopa hurongwa hwekushanda hwekubatanidza mabasa ezvirwere zvepabonde munzvimbo dzehutano hwepakutanga, munharaunda, HIV, hutano hwekubereka, uye mapuratifomu ehutano hwaamai nevana. Panyaya yekuongorora chirwere, pane zvinhu zvitatu zvakakosha zvinobuda:
Kubatanidzwa kwemapuratifomu akasiyana-siyana— zvinoda maturusi ekuongorora anoshanda nemazvo nemhando dzakasiyana dzesampuli (weti, urethra, cervical, vaginal swabs)
Mari inoenderera mberi— sezvo nyika dzichichinja kubva pakutsigira vanopa mari kuenda kubhajeti remuno, kushandisa mari zvakanaka kunova kwakakosha. Multiplex NAAT inoderedza mutengo we reagent yehutachiona hwega, nguva yekushanda, uye nguva yekushanda zvichienzaniswa nekuyedza kwakawanda kwechinangwa chimwe chete, zvichiita kuti kufukidzwa kwakawanda kuwedzere pasina mari yekudyara muzvivakwa zvakaenzana.
Kutarisira mabhakitiriya— kuziva utachiona hwakakwana kunotsigira kurapwa kwakanangana nechirwere pane kurapwa kwakaitwa nenyanzvi, nzira huru yekuderedza kusakwanisa kurwisa mabhakitiriya eN. gonorrhoeae.
3. Chigadzirwa cheScreening Portfolio yeMacro & Micro-Test Tiered STI
3.1 Uzivi hweKugadzira: Kubva paKunyatsojeka kweTarget kusvika paKufukidzwa kwePanoramic
Zvichibva pazvinodiwa zvekuongorora STI zvisina zviratidzo kubva kuWHO [1,2,4] uye kubvumirana kwepasi rose pakuongororwa kwemultiplex senzira yehutano hweveruzhinji [5], Macro & Micro-Test yakagadzira portfolio yekuongorora STI nucleic acid kubva kuchinangwa chimwe chete kusvika kune ultra-broad-spectrumkuwanikwa. Zvigadzirwa zvese zvinoshandisaKupenya kwePCRkanaEnzymatic Probe Isothermal Amplification (EPIA)mapuratifomu, ane mhando dzemienzaniso dzinofukidza weti, machira emuura evarume, machira emumuromo wemukadzi, uye machira emudumbu, zvichibatsira mumamiriro akasiyana-siyana ekurapa uye zvinodiwa pakuongorora huwandu hwevanhu.
| Panel | Nzvimbo Yakatarwa | Mhando dzeMienzaniso | LoD | Kushandiswa kweKliniki |
| Chinangwa Chimwe Chete | Chirwere chimwe chete | Maswiti / weti | Makopi 400–1000/mL | Kuongororwa kwezviratidzo zvehutachiona, kuongororwa kwekurapwa |
| Triplex | Misanganiswa mitatu inowanzo shandiswa yezvirwere | Maswiti / weti | Makopi 400–1000/mL | Kuongororwa kwezvirwere zvepabonde nguva dzose, kuongororwa kwepamuviri nguva isati yakwana |
| 7-Plex | NG, CT, UU, HSV1, HSV2, Mh, Mg | Maswiti / weti | Makopi 400–1000/mL | Kuongororwa kwakazara kwehutachiona hwepolymicrobial muvanhu vose uye vari pangozi huru |
| 9-Plex | CT, NG, Mh, HSV1, UU, HSV2, UP, MG, TV | Maswiti / weti | Makopi 400–1000/mL | Kuongororwa kwakazara kwehutachiona hwepolymicrobial muvanhu vose uye vari pangozi huru |
| 14-Plex | CT, MG, MH, HSV1, HSV2, UU, UP, MG, CA, GV, TV, GBS, HD, TP | Maswiti / weti | Makopi 400–1000/mL | Kuongororwa kwakazara kwehutachiona hwepolymicrobial muvanhu vose uye vari pangozi huru |
| 18-Plex | CT, NG, Mh, HSV1, UU, HSV2, UP, MG, CA, GV, TV, GBS, HD, TP, CKR, CG, CPA ,CTR | Maswiti / weti | Makopi 400–1000/mL | Yakanyatsojeka yehutachiona hwema microbial, kuongororwa kwezvikonzero zvezvirwere zvakaoma, zvinodzokororwa, kana zvisingadi kurapwa; tsvakurudzo ne epidemiology |
3.2 Kuona Chinhu Chiri Chete: Kuziva Nzvimbo Yacho Nekunyatsoongorora
Kune vanhu vane zviratidzo zvakajeka zvekiriniki kana avo vane mhedzisiro yekutanga yekuongorora inoratidza chirwere chakati, NAAT ine chinangwa chimwe chete inopa nzira chaiyo uye inodhura yekusimbisa. Macro & Micro-Test inopa makit ane chinangwa chimwe chete anofukidza hutachiona hweSTI hukuru, kusanganisira CT, NG, UU, Mh, MG, TV, HSV1/2, TP, uye Candida species, nekunzwa kwekuongorora kwakaderera kusvikaMakopi makumi mashanu/mhinduro(semuenzaniso, HWTS-UR007 HSV-2 detection kit), ichipa humbowo hwakajeka hwezvikonzero zvinotungamira kurapwa kwakarurama uye manejimendi evadyidzani.
Nzvimbo yekiriniki:Kusimbiswa kwezviratidzo zvinofungidzirwa kuti zvine hutachiona hweSTI; kutarisa kwemasero emushonga unorwisa mabhakitiriya; kuongororwa kwakanangana mushure mekusangana nehutachiona hwakanyanya.
3.3 Kuongororwa kweTriplex: Sarudzo Yekutanga Yekuongorora Kwepakutanga
Zvigadzirwa zveTriplex zvinoshanda zvakanyanya pakuongororwa kweSTI nguva dzose. Zvichitungamirirwa nenhungamiro dzeWHO dza2025 dzakanyanya kusimbiswa pakuongororwa kweCT neNG [1] uye dzichifunga nezvemaprofiles enzvimbo epidemiological, Macro & Micro-Test yakagadzira misanganiswa yakati wandei yetriplex:
-HWTS-UR019 (CT + UU + NG): Inofukidza musanganiswa weSTI webhakitiriya wakanyanya kuwanda pasi rose;-HWTS-UR043 (CT + UU + MG): NeMycoplasma genitalium (MG), iyo yava chinhu chinonyanya kukosha mukurapa nekuda kwekusakwanisa kwayo kupindura mishonga.
-HWTS-UR044 (Mh + UU + GV): Kune utachiona hunowanzo sangana nehutachiona hwebhakitiriya uye hutachiona hwakasiyana hwechikadzi.
-HWTS-UR041 (CT + NG + TV): Inofukidza musanganiswa wakajairika wezvirwere zvepabonde zvebhakitiriya neprotozoal.
Nzvimbo yekiriniki:Kuongororwa hutano hwepabonde nguva dzose uye kuongororwa kwepamuviri panguva yekuzvitakura (kudzivirira kutapurirana kubva kuna amai kuenda kumwana); kuongororwa kwegore negore kana kwehafu yegore kwevanhu vane njodzi huru (vechidiki, varume nevakadzi vanoita zvepabonde, vanoita zvepabonde).
3.4 Kuedzwa kwe7-Plex ne9-Plex: Sarudzo Dzepamusoro dzeKuongorora Kwakakwana
Kana kuongororwa kwenjodzi dzekiriniki kuchiratidza mukana wekuti pave nezvirwere zvakawanda panguva imwe chete kana kuti pave nekuongororwa kwakanyatsojeka kwevanhu vane njodzi huru, zvigadzirwa zve7-plex ne9-plex zvinopa mukana wekuona chirwere ichi zvakanyanya.
-HWTS-UR012 (7-Plex): Inotarisa NG, CT, UU, HSV1, HSV2, Mh, uye Mg, ichifukidza hutachiona hweSTI hunowanzo shandiswa nemabhakitiriya, mavhairasi, uye mycoplasmal. LoD: 400 makopi/mL kune ese kunze kweMh (makopi 1000/mL).
-HWTS-UR048 (9-Plex): Inoona CT, NG, Mh, HSV1, UU, HSV2, UP, MG, uye TV, hutachiona hupfumbamwe hunofukidza gonococcus, chlamydia, mycoplasmas (kusanganisira Ureaplasma parvum), herpes simplex virus, uye Trichomonas vaginalis, inomiririra imwe yepaneru dzakakwana mukirasi yayo.
Nzvimbo yekiriniki:Kuongororwa kwakazara kwezvirwere zvepabonde (STI) kuti zvishandiswe muzvipatara nguva dzose muvanhu vazhinji, kusanganisira vanhu vane zviratidzo uye vasina zviratidzo; kuongororwa vasati vabata pamuviri uye vasati vabata pamuviri; uye kuongororwa kwechipiri kana kuongororwa kwekutanga kwakanangana nechirwere ichi kuchiratidza mhedzisiro yakaipa pasinei nekufungidzirwa kwekiriniki nguva dzose.
3.5 Kuedzwa kwe14-Plex: Kuongororwa kweBroad-Spectrum Kusingapotse Pathogen "Yakanyarara"
Chigadzirwa che14-Plex chinomiririra kuzadzikiswa kwetekinoroji kwepfungwa ye "kuongorora kushingaira" inotsigirwa nenhungamiro dzeWHO[1,2].HWTS-UR040anoona panguva imwe chete14 utachiona hwenhengo dzesikarudzi: CT, NG, Mh, HSV1, HSV2, UU, UP, MG, CA, GV, TV, GBS, HD, uye TP. Panel iyi inosanganisira:
-Mabhakitiriya: CT, NG, GV, GBS (Boka B Streptococcus, inotarisa pamuviri)
-Mycoplasmas: Mh, UU, UP, MG (marudzi ese mana e mycoplasma)
-Mavhairasi: HSV1, HSV2, HD
-Mapuroteni: TV (Trichomonas vaginalis)
-Spirochetes: TP (Treponema pallidum, syphilis)
Boka iri rinonyatsoongorora muenzaniso wekuongorora we "sampuli imwe chete, kuferefeta kwakazara", wakakodzera kuferefeta kwakarongeka kwezvirwere kana zviratidzo zvakajeka kana nzvimbo dzehutachiona dzisina.
Nzvimbo yekiriniki:Kusagadzikana kwenguva refu kwenhengo dzesikarudzi dzisina kutsanangurwa; hutachiona hwenjovhera hunodzokororwa; kuongororwa kwehutachiona hwesikarudzi hune chekuita nekusabereka; kuferefetwa kwezvirwere zvakasiyana-siyana zvevanhu.
3.6 Kuedzwa kwe18-Plex: Ultra-Broad-Spectrum "Gold Standard"
HWTS-UR052ndiyo panel yekuongorora STI yakawanda yeMacro & Micro-Test kusvika pari zvino, ichiongorora panguva imwe chete18 utachiona hwehutachiona hwenhengo dzemudumbu: CT, NG, Mh, HSV1, UU, HSV2, UP, MG, CA, GV, TV, GBS, HD, TP, CKR, CG, CPA, uye CTR. Zvichibva papaneru ye14-Plex, chipo ichi chinowedzera kufukidzwa kusvika pahuwandu hwakakura hwezvirwere, kusanganisira:
-Chlamydia trachomatiszvine chekuita nazvo: CKR, CG, CTR (chlamydial typing uye zvimwe zvirwere zvine chekuita nazvo)
-Candidamhando: CA (Candida albicans) — chirwere chefungus chinowanzo wanikwa munhengo dzesikarudzi dzevakadzi
Kupararira kwebhakitiriya: Kusanganisira Gardnerella vaginalis neBoka B Streptococcus
Nzvimbo yekiriniki:Kuferefeta kwakazara kwezvirwere zvakaoma zvenhengo dzesikarudzi; kuferefeta nekuongorora zvirwere; nyaya dzinonetsa dzine zviratidzo zvisina kunaka mushure mekuongororwa kwepanel; kuongororwa kwakadzika kwezvirwere zvepabonde panzvimbo dzekuongorora hutano dzepamusoro.
4.Kupindura WHO'Kudanwa Kwekuvaka Muganho Mutsva Wekudzivirira Nekudzora Njodzi Dzepabonde
Gwaro reWHO ra2025–2026 rinoda kuti kuongororwa kwevarwere vasina zviratidzo kuwedzere, kubatanidzwa kwesevhisi, uye kuongororwa kwemultiplex.Matrix yechigadzirwa chekuongorora mamorekuru cheMacro & Micro-Test cheSTI multiplex, chine dhizaini yaro kubva pakuona kwechinangwa chimwe chete kusvika pakuona kwe18-plex, imhinduro yakananga kune iyi nzira yepasi rose yehutano. Ingave kuongororwa kwetriplex kunoitwa muzvipatara zvepuraimari kana kuferefetwa kwakadzika kwakavakirwa pakuyedzwa kwe14-plex kana 18-plex muzvipatara zvepamusoro uye mumarabhoritari eCDC, zvigadzirwa zvedu zvinopa kunzwisisika kwakanyanya (400 copies/mL zvishoma), throughput yakakwira, uye specific high.
PaVhiki yeKuzivisa Njodzi Dzepabonde 2026 (Kubvumbi 12–18), Macro & Micro-Test inosimbisa kuzvipira kwayo kutsigira kuongororwa kwakazara kwenjodzi dzepabonde uye kugonesa masangano ehutano kuti atore nzira dzeNAAT-based multiplex - kufambira mberi pamwe chete kuzvinangwa zveWHO 2030 zvekuderedza nyaya itsva dzesyphilis, gonorrhea, chlamydia uye trichomoniasis, uye kugumisa denda renjodzi dzepabonde.
Kunyarara hakusi kuchengetedzeka— Macro & Micro-Test inopa izwi kuhutachiona husinganzwi.
Kuti uwane rumwe ruzivo:marketing@mmtest.com
Mareferensi
[1] Sangano reHutano rePasirose. Mitemo yekutarisira hutachiona hwepabonde husina zviratidzo. Geneva: Sangano reHutano rePasirose; 2025.
[2] Sangano reHutano rePasirose. Mazano ekupa rubatsiro rwehutano mukudzivirira nekutarisira hutachiona hwepabonde. Geneva: Sangano reHutano rePasirose; 2025.
[3] Sangano reHutano rePasirose. Bhuku reWHO rakabatanidzwa pamusoro pezvirwere zvinotapuriranwa pabonde. Geneva: Sangano reHutano rePasirose; 2026.
[4] Sangano reHutano rePasirose. Pfupiso yekurudziro dzeWHO pamusoro pekuongororwa kweHIV nehutachiona hwepabonde, kudzivirira, kurapwa, kutarisirwa uye kupa masevhisi. Geneva: Sangano reHutano rePasirose; 2025.
[5] Sangano reHutano rePasirose. WHO inozivisa kugadzirwa kwenhungamiro dzekuongororwa kwemultiplex. Geneva: Sangano reHutano rePasirose; 2025.
Nguva yekutumira: Kubvumbi-13-2026