Munguva pfupi yapfuura,China CDC Vhiki Nevhikiyakaburitsa chinyorwa chakakosha chekutsvagisa chinotsanangura kuferefeta kwezvirwere uye etiological kwechirwere chegomarara chakakonzerwa neGroup C rotavirus (RVC) pachikoro chepuraimari muLuzhou, Sichuan Province, muna Gumiguru 2025. Zvinonyanya kukosha, Macro & Micro-Test's high-throughput targeted pathogen capture kit (probe-capture) uye whole-genome enrichment sequencing technology zvakaita basa guru mukuferefeta. Nekugonesa kuzivikanwa kwezvirwere nemazvo uye kutsanangurwa kwakakwana kwemajini, tekinoroji iyi yakapa humbowo hwakakosha hwesainzi hwekusimbisa kupararira kwechirwere nekukurumidza, kutsvaga kwakarurama kwakabva chirwere, uye kudzora kupararira kwechirwere zvinobudirira.
Kupararira Kwechirwere Chemanyoka: Kupararira Kwechirwere Chemanyoka Chekutanga Kunonzi Kunobuda muSouthwest China
Musi wa15 Gumiguru 2025, chirwere chemudumbu chakaitika pachikoro chepuraimari muLuzhou. Chikoro ichi chaive nevanhu 1,943 nevashandi, nevanhu 32 vakabatwa nechirwere ichi, kusanganisira vanhu 6 vakaongororwa murabhoritari uye vanhu 26 vakaonekwa kuti vane chirwere ichi, zvikaita kuti chirwere ichi chive ne1.65%. Kupararira kwacho kwakasvika pakati pa15 na16 Gumiguru, uye veKirasi 7, Giredhi 5 vakabatwa nechirwere ichi zvakanyanya (23.08%). Varwere vazhinji vaive vana vezera rechikoro (zera repakati: makore gumi), vainyanya kurutsa (65.62%), manyoka (46.87%), uye kurwadziwa mudumbu (37.50%). Zviratidzo izvi zvaiwanzotora mazuva 1-3, uye varwere vese vakapora vasina matambudziko akakomba.
Ongororo yezvirwere yakaratidza kuti munhu uyu aive mukomana ane makore gumi nerimwe ekuberekwa ari muGiredhi 7, Giredhi 5. Hanzvadzi yake diki yakanga yaratidza zviratidzo zvakafanana nezvayo, zvichiratidza kuti kutapurirana kwechirwere mudzimba ndiko kwaitanga. Kusagona kutarisirwa kwemarutsi pachikoro—kusanganisira kutsvaira zvakananga nekurasa tsvina pasina kuvhiyiwa mushonga panguva yakakodzera kana kuparadzaniswa—pamwe chete nekusachena kwemaoko pakati pevadzidzi, zvingangodaro zvakaita kuti kutapurirana kwacho kuve kwakawanda. Makirasi mazhinji akakanganiswa aive pakati pedura rechipiri nerechishanu uye zvimbuzi zvevarume zvaive pedyo, zvichiratidza kuti zvese aerosol nekutapurirana kwechirwere zvinogona kunge zvakakonzera kupararira kwacho.
Kuferefeta kwacho kwakava kwakaoma zvikuru nekuti kuongororwa kwezvirwere nguva dzose, kusanganisira kuongororwa kwenorovirus neboka reRotavirus reBoka A, kwakaburitsa mhedzisiro isina kunaka, zvichiratidza kuti utachiona husingawanzoitiki ndihwo hwakakonzera.
Kuongororwa kweEtiological: Macro & Micro-Test's Whole-Genome Sequencing Inozivisa Chinokonzera Dambudziko
Kuongororwa kwekutanga kwe norovirus kwaive kusina kunaka. Chipatara cheLuzhou CDC chakazoshandisa nzira yekuongorora chirwere che multiplex gastrointestinal pathogen real-time PCR, iyo yaikwanisa kuona hutachiona makumi maviri nemasere panguva imwe chete, kusanganisira mavhairasi masere, mabhakitiriya gumi nemanomwe, uye tupukanana tutatu, kuti vaongorore sampuli sere dzekiriniki. Musi wa17 Gumiguru, sampuli nhanhatu dzakaonekwa kuti dzine rotavirus yeboka C, dzichibva dzaona chirwere chacho chinokonzera chirwere ichi.
Kuti varambe vachiongorora kwakabva chirwere ichi, vaongorori vakaita zvese nanopore metagenomic sequencing pamwe neMacro & Micro-Test's probe-catch whole-genome enrichment sequencing pamasampuli mashanu akanaka. Nzira iyi yakabudirira kugadzira maRVC genome sequences mashanu akazara (SC01–SC05). Nzira yakabatana yekuongorora nekukurumidza multiplex PCR ichiteverwa nehigh-resolution whole-genome sequencing yakapa rutsigiro rwakasimba rwehunyanzvi hwekuongorora epidemiology chaiyo uye kutsvaga masource.
Kuziva Sainzi: Kuzivikanwa Kwekutanga kweM2 Genotype kuSouthwest China
Zvichibva padata remhando yepamusoro remajini ese rakagadzirwa uchishandisa tekinoroji yeMacro & Micro-Test, timu yekutsvagisa yakashuma zvakawanikwa nesainzi zvakakosha:
Kusimbiswa kwechirwere chemonoclonal:Mavhairasi ese mashanu akapatsanurwa aive negenotype yakafanana yegenome yese (G4-P[2]-I2-R2-C2-M2-A2-N2-T2-E2-H2), ine musiyano we 0-1 single nucleotide polymorphism (SNP) chete, zvichiratidza pachena kuti denda iri rakabva kune imwe chete nzira yekuparadzira utachiona.
Kuwanikwa kwemhando yeM2:Ongororo yephylogenetic yakaratidza kuti mhando dzeLuzhou RVC dzaive dzemhando yeM2 kwete mhando yeM3 yaimboonekwa seyakanyanya kuwanda pakati pemhando dzeRVC dzekuChina. Kuwanikwa uku kunonetsa kunzwisisa kwakajairika kwekupararira kwemhando yeRVC muChina uye kunosimbisa kubuda kwemhando yeM2 kumaodzanyemba kwakadziva kumadokero kweChina.
Humbowo hwekubatana kwekutumira kwepasi rose:Kuenzanisa majini ese kwakaratidza kufanana kukuru kwemajini pakati pemarudzi eLuzhou nemarudzi eRVC akambotaurwa muYunnan (2025), Novosibirsk, Russia (2017), neItaly (2012), zvichiratidza kuvapo kwenetwork inoshanda yekutumira utachiona kuEurasian.
Zvinokonzera Kudzivirira uye Kudzora: Kuwanikwa Kwechirwere Chekutanga uye Kukurumidza Kupindira Zvakakosha
Mushure mekuonekwa kwehutachiona, Luzhou CDC yakabva yatanga matanho ekudzora akazara, anosanganisira kupatsanura vanhu, kubvisa utachiona munzvimbo inovapoteredza, kugadzirisa kurutsa kwakajairika, uye kumisa kwenguva pfupi chirwere ichi. Kupararira kwechirwere ichi kwakagadziriswa zvakanaka mukati menguva imwe chete yekuyamwisa, pasina mimwe nyaya yakataurwa mushure me21 Gumiguru.
Ongororo iyi inopawo chidzidzo chakakosha chehutano hweveruzhinji: kune kubuda kwechirwere chegastroenteritis kwakasanganiswa uko kunoonekwa kusina hutachiona hweRotavirus neRorovirus muBoka A, Rotavirus yeBoka C nedzimwe rotavirus dzisiri dzeBoka A dzinofanira kuiswa muongororo yenguva dzose.
Chidzidzo ichi chinomiririra kubuda kwekutanga kwechirwere cherotavirus cheGroup C kumaodzanyemba kwakadziva kumadokero kweChina uye kuzivikanwa kwekutanga kweM2 genotype munharaunda iyi, zvichiwedzera kunzwisisa kwazvino kweRVC epidemiology muEast Asia. Mukuferefeta uku, mhinduro yakabatanidzwa yeMacro & Micro-Test inosanganisa multiplex PCR screening ne whole-genome enrichment sequencing yakaratidza kukosha kwakakosha nekuita kuti pave nekuzivikanwa nekukurumidza kwehutachiona uye kuteverwa kwemamorekuru ane resolution yepamusoro, zvichipa hurongwa hwehunyanzvi hwekudzokorora kuferefeta kwakarurama uye kudzora kubuda kwezvirwere zvinotapukira mune ramangwana.
Nguva yekutumira: Chikunguru-30-2026