Kuvandudzwa muKuongororwa kweGomarara reMuromo: Kurongeka kweNhungamiro dzeWHO neChirongwa Chekuona HPV Chine HPV Yakakura Zvikuru

1. Mutoro wepasi rose weGomarara reMuromo uye Matambudziko ekuongororwa

Gomarara remuchibereko richiri dambudziko guru rehutano hwevanhu pasi rose, kunyangwe richigona kudzivirirwa zvakanyanya kuburikidza nekuongororwa zvinobudirira uye kupindira nekukurumidza. Sekureva kweWorld Health Organization (WHO), nyaya itsva dzinosvika 662,000 uye kufa kwevanhu 349,000 kwakaitika pasi rose muna 2022, zvichiratidza kuti iri kenza yechina inonyanya kuwanda uye chikonzero chechina chekufa kwevanhukadzi nekuda kwegomarara. Mutoro wezvirwere wakanyanya kuwanda munyika dzine mari shoma nepakati (LMICs), uko kuwanda kwehuwandu hwevanhu vanofa kwakanyanya kupfuura munzvimbo dzine mari yakawanda. Izvi zvinonyanya kukonzerwa nekushaikwa kwezvirongwa zvekuongorora zvemhando yepamusoro uye kuona nekurapa maronda asati aita gomarara, zvichiwedzerwa ne:

-Kusavapo kana kusasimba kwehurongwa hwekuongorora:Kushaikwa kwemabasa ekuongorora anowanikwa nyore nyore uye ane hunhu hwakanaka.

-Zvipingamupinyi zvezviwanikwa:Zvivakwa zvemarabhoritari zvishoma, zvinhu zvinofambiswa nemhepo, uye magetsi akavimbika.

-Kushomeka kwevashandi:Kushaikwa kwevashandi vakadzidziswa murabhoritari nekiriniki.

-Kunonoka uye kurasikirwa nekutevera:Nguva yekunonoka pakati pekutorwa kwesampuli uye kuwanikwa kwemhedzisiro, zvichikonzera kunonoka mukutarisira kwekiriniki kana kuti varwere varasikirwe nekutevera [1].

2. Etiology uye Molecular Basis yeCervical Carcinogenesis

Kutapukirwa kusingaperi nehutachiona hwepapilloma hwevanhu (HR-HPV) hune njodzi huru ndicho chikonzero chakakosha chegomarara remuchibereko. Pakati pemhando dzeHPV dzinopfuura mazana maviri dzakaonekwa, dzinenge gumi nembiri dzakaiswa muboka rekuti dzinokonzera kenza (Boka 1) neInternational Agency for Research on Cancer (IARC).

Padanho remamorekuru, chirwere chekenza chinokonzerwa neHPV chinonyanya kukonzerwa nemavirusi e oncoproteins E6 neE7. E6 inokurudzira kudzikira kweprotein p53 inodzvinyirira bundu, ukuwo E7 ichimisa retinoblastoma protein (Rb) zvichikonzera kusashanda zvakanaka kwemasero uye kushanduka kwemaronda.

3. Nzira dzekuongorora dzinokurudzirwa neWHO

Sangano reWorld Health Organization rinokurudzira kuongororwa kweHPV nucleic acid (NAT) senzira yekutanga yekuongorora chirwere ichi yekudzivirira gomarara remumuromo wechibereko.

Huwandu hwevanhu vose:HPV DNA kana mRNA-based NATs

Vakadzi vanorarama neHIV:MaNAT akavakirwa paHPV DNA

Nguva dzekuongorora:

Vakadzi vane makore 30-65: Makore mashanu kusvika gumi ega ega

Vakadzi vanorarama neHIV: Makore matatu kusvika mashanu ega ega

Kuongororwa kweHPV kunoratidza kuti kana tichienzanisa nenzira dzinoshandiswa pakuongorora chirwere chetsvo (cytology)kunzwa kwakanyanyauye inopakukosha kwakanyanya kwekufanotaura kusina kunaka, zvichiita kuti nguva dzekuongorora dzive dzakareba uye dzisingadhuri.

4. WHO inotarisira chigadzirwa chekuongorora HPV

WHO yakagadzira chirongwa cheNhoroondo Yechigadzirwa Chinotarisirwa (TPP)yekuongorora HPV yakagadzirirwa kushandiswa munzvimbo dzakatarwa uye dzisina zviwanikwa zvakawanda.[1]

Hunhu hukuru hunosanganisira:

-Kuenderana nemuenzaniso wakaunganidzwa wega

-Kuonekwa kwemhando dzakasiyana dzeHPV dzine njodzi huru (≥mhando gumi nembiri)

-Kushandiswa nevashandi vasina kudzidziswa murabhoritari

-Mhedzisiro inowanikwa mukati mechiitiko chimwe chete chekiriniki

Izvi zvinotsigira kuongororwa kwevarwere panzvimbo yekurapwa uye nzira dze "kuongorora nekurapa".

5. Nzvimbo Yekuona HPV Inoshanda Yoga Yega Ine Njodzi Yakawanda

Sisitimu yeMacro & Micro-Test yeAIO800 inopanzira yekushanda yeSample-to-respond yakazara otomatikikubatanidza kuburitswa kwe nucleic acid, kuwedzerwa, uye kuonekwa kwayo zvichienderana nehurongwa hwekuongorora hunokurudzirwa neWHO.

5.1 Kufamba Kwebasa reSample-to-Answer otomatiki

Puratifomu iyi inobatanidza kuburitswa kwe nucleic acid, kuwedzerwa, uye kuonekwa kwayo muhurongwa humwe chete, hwakavharwa, zvichida kupindira kushoma kwemushandisi. Dhizaini iyi:

-Inoderedza kuvimba nevashandi vepa laboratory vane hunyanzvi

-Inoderedza kusiyana kwemaitiro uye njodzi yekusvibiswa

- Inobvumira kutumirwa munzvimbo dzehutano dzakaparadzaniswa

Panguva imwe chete, kugona kwayo kushanda kunotsigira kushandiswa mumarabhoritari ari pakati nepakati, zvichiita kuti zvirongwa zvekuongorora zvive nyore.

5.2 Kufukidzwa Kwakakura Kwemajini

Sisitimu iyi inoongorora mhando gumi nemana dzeHPV dzine njodzi huru, kusanganisira mhando dzese gumi nembiri dzinokonzera kenza dzakarongwa neIARC (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, uye 59), pamwe neHPV66 neHPV68.

Chinonyanya kukosha, inoparudzi rwe genotypingmhedzisiro, zvichiita kuti njodzi dzive dzakarongwa uye kuti kurapwa kwacho kuve kwakanyatsojeka.

5.3 Kunzwisisa Kwepfungwa Nemigumisiro Yekiriniki

Nekuganhurirwa kwekuonekwa kwemakopi mazana matatu pa mL, hurongwa uhu hunokwanisa kuona hutachiona hweHPV hwakaderera hunokonzera:

-Kuonekwa kwezvirwere zvine chekuita nekiriniki nguva isati yakwana

-Kukosha kwekufanotaura kwakaderera kwakawedzera

-Rutsigiro rwekureba kwenguva dzekuongorora

5.4 Rutsigiro rweKuzvisarudzira

Puratifomu iyi inoenderana nezvose zviri zvivirisampuro dzemushonga wemuromo wechibereko uye sampuro dzeweti dzakaunganidzwa wegakuenderana nekurudziro dzeWHO kugadzirisa zvipingamupinyi zvikuru pakushandiswa kweongororo, zvinosanganisira:

-Kuwanikwa kwezvipo zvehutano kwakaderera

-Zvipingamupinyi zvetsika nemagariro evanhu

-Kusagadzikana kwemurwere nekuongororwa kwakaitwa nachiremba

Kuzvisarudzira pachako kwakaratidzwa kuti kunowedzera kutora chikamu muzvirongwa zvekuongorora, kunyanya pakati pevanhu vasina rubatsiro rwakakwana.

5.5 Tekinoroji yeReagent Yakapfava Yekuchengetera Zvinhu Zviri Mukati

Kuti zviwedzere kushandiswa munzvimbo dzisina zviwanikwa zvakawanda, sisitimu iyi inosanganisirazvinogadzirisa lyophilized (zvakaomeswa nechando)dzakagadzikana pakupisa kwekunze, zvichipa mabhenefiti akawanda ekushanda:

-Kuzvimiririra muchando: Kubvisa kudiwa kwekutakura nekuchengetedza mufiriji

-Kugadzikana kwakawedzerwa: Kuchengetedza reagent yakasimba pasi pemamiriro ezvinhu akasiyana-siyana

-Zvinhu zviri nyore kushandisa: Zvinoderedza zvinodiwa muzvivakwa uye mari yekushandisa

-Kuwanikwa kwakawedzerwa: Kunobatsira kutumirwa kunzvimbo dziri kure kana kuti dzisina kuchengetwa zvakakwana

6. Mhedziso

Kuchinja kubva pakuongororwa kwemasero eropa kuenda pakuongororwa kwemasero eropa neHPV kunomiririra shanduko huru mukudzivirira gomarara remumuromo wechibereko. Nekutarisa chikonzero chechirwere pane kuchinja kwechimiro, kuongororwa kweHPV kunogonesakuonekwa kwekutanga uye kwakanyatsojekayevanhu vari panjodzi.

Uyezve, mapuratifomu ekuongorora mamorekuru anoshanda otomatiki anopa nzira inoshanda yekukunda zvipingamupinyi zviripo pakupa kuongororwa.kushanda kwepamusoro kwekuongorora nekushanda kuri nyore uye rutsigiro rwekuzvisarudzira,AIO800 ine mukana wekuwedzera huwandu hwekuongorora, kuvandudza kuwanikwa kwechirwere ichi nekukurumidza, uye kubatsira mukuderedza mutoro wepasi rose wegomarara remuchibereko.

Mareferensi:

1. Sangano reHutano rePasirose. Ronga maprofile ezvigadzirwa kuti zviongororwe papillomavirus yevanhu kuti zvionekwe kenza yemumuromo wechibereko isati yatanga. Geneva: WHO; 2024.