Chii chinokonzera hutachiona hweC. Diff?
Utachiona hweC.Diff hunokonzerwa nebhakitiriya rinozivikanwa seClostridioides difficile (C. difficile), iyo inowanzogara muura isina njodzi. Zvisinei, kana hutachiona hwemudumbu hukakanganiswa, kazhinji kushandiswa kwemishonga inorwisa mabhakitiriya yakawanda, C. difficile inogona kukura zvakanyanya uye kugadzira chepfu, zvichikonzera hutachiona.
Bakiteri iyi iripo mune ese ari mavirizvinokonzera chepfuuye mafomu asina chepfu, asi marudzi etoxigen (toxin A naB) ndiwo chete anokonzera chirwere. Anokonzera kuzvimba nekukanganisa masero emudumbu. Toxin A inonyanya kukuvadza dumbu, ichiwedzera kupinda kwemvura, uye inokwezva masero ekudzivirira muviri anoburitsa ma cytokines anokonzera kuzvimba. Toxin B, cytotoxin ine simba, inotarisa actin cytoskeleton yemasero, zvichikonzera kutenderera kwemasero, kubviswa, uye pakupedzisira kufa kwemasero. Pamwe chete, chepfu idzi dzinokonzera kukuvara kwematishu uye mhinduro yakasimba yekudzivirira muviri, iyo inoratidzwa se colitis, manyoka, uye mune zviitiko zvakakomba, pseudomembranous colitis—kuzvimba kwakakomba kweura.
Zvinoita seiC. Kusiyanaparadzira?
C.Diff inopararira zviri nyore. Inowanikwa muzvipatara, inowanzo kuwanikwa muICUs, mumaoko evashandi vechipatara, pasi pezvipatara uye pamaoko, pama thermometers emagetsi, nemimwe michina yekurapa...
Zvinhu Zvinokonzera Njodzi dzeC. Diff Infection
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●Kugara muchipatara kwenguva refu; -
●Kurapa kwehutachiona; -
●mishonga yekurapa nemakemikari; -
●Kuvhiyiwa kuchangobva kuitwa (maoko emudumbu, gastric bypass, kuvhiyiwa kweura hukuru); -
●Kudya kunovaka muviri mudumbu; -
●Utachiona hweC. diff husati hwatanga;
Zviratidzo zvehutachiona hweC. Diff
Chirwere cheC. diff chinogona kusafadza. Vanhu vazhinji vane manyoka anoramba achiitika uye kusagadzikana mudumbu. Zviratidzo zvinonyanya kuzivikanwa ndeizvi: manyoka, kurwadziwa mudumbu, kuda kurutsa, kurasikirwa nechido chekudya, fivha.
Sezvo hutachiona hweC. diff huchiwedzera kuipa, pachava nekukura kwerudzi rwakaomarara rweC. diff runozivikanwa secolitis, pseudomembranous enteritis uye kunyange rufu.
Kuongorora chirwereyeC. Diff Infection
Tsika yeMabhakitiriya:Inonetsa asi inotora nguva (mazuva 2-5), haigone kusiyanisa mhando dzezvirwere zvinokonzera chepfu nedzisina chepfu;
Tsika yeChepfu:inoona mhando dzezvirwere zvinokonzera chepfu asi zvinotora nguva yakareba (mazuva 3-5) uye zvisinganyanyi kubatwa nechirwere ichi;
Kuonekwa kweGDH:inokurumidza (1-2hrs) uye inodhura zvishoma, inononoka zvikuru asi haigone kusiyanisa mhando dzezvirwere zvinokonzera chepfu nedzisina chepfu;
Kuyedzwa kweCytotoxicity Neutralization Assay (CCNA):inoona chepfu A neB ine hunhu hwakanyanya asi inotora nguva (mazuva maviri kusvika matatu), uye inoda nzvimbo dzakanyatsogadzirwa nevashandi vakadzidziswa;
Toxin A/B ELISA: Bvunzo iri nyore uye inokurumidza (1-2hrs) ine kusanzwisisika kwakaderera uye zviratidzo zvenhema zvinowanzoonekwa;
Miedzo yeNucleic Acid Amplification (NAATs): Inokurumidza (1-3hrs) uye inonyanya kunzwa uye yakananga, ichiona majini anokonzera kugadzirwa kwechepfu;
Pamusoro pezvo, bvunzo dzekuongorora ura, dzakadai seCT scans neX-rays, dzinogona kushandiswawo kubatsira mukuongorora C. diff uye matambudziko eC. diff, akadai secolitis.
Kurapa kwehutachiona hweC. Diff
Nzira dzakawanda dzekurapa dziripoC. hutachiona hwe diffHeano sarudzo dzakanakisa:
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●Mishonga inorwisa mabhakitiriya inonwiwa senge vancomycin, metronidazole kana fidaxomicin inowanzo shandiswa sezvo mushonga unogona kupfuura nemudumbu wosvika muura hunogara mabhakitiriya eC. diff. -
●Metronidazole inopinzwa mutsinga inogona kushandiswa kurapa kana hutachiona hweC. diff hwakanyanya. -
●Kuisirwa kwe microbiota kubva mutsvina kwakaratidza kushanda zvakanaka mukurapa hutachiona hweC. diff hunowanzoitika uye hutachiona hweC. diff hwakakomba husingapindure nemishonga inorwisa mabhakitiriya. -
●Kuvhiyiwa kunogona kudiwa kana paine chirwere chakanyanya.
Mhinduro yekuongorora kubva kuMMT
Mukupindura kudiwa kwekukurumidza uye kwakarurama kwekuona C. difficile, tinopa Nucleic Acid Detection Kit yedu itsva yeClostridium difficile toxin A/B gene, tichipa simba kune vashandi vehutano kuti vaongorore nekukurumidza uye nemazvo uye kutsigira kurwisa hutachiona hunowanikwa muchipatara.
●Kunzwa Kwakanyanya: Inoona yakaderera se200 CFU/mL,;
●Kunangwa Kwakarurama: Inonyatsoona jini reA/B rine chepfu yeC. difficile, ichideredza zviratidzo zvenhema;
●Kuonekwa Kwehutachiona Hwakananga: Inoshandisa nucleic acid testing kuti ione zvakananga majini etoxin, zvichigadzira mwero wepamusoro wekuongorora.
●Inoenderana zvizere nezvishandiso zvePCR zvinobata ma laboratori akawanda;
Muenzaniso weMhinduroMhinduro paMacro & Micro-Test's AIO800 Mobile PCR Lab
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●Kugadzira Sample-to-Answer Automation – Isa machubhu ekutanga emuenzaniso (1.5–12 mL) zvakananga, uchibvisa mapaipi emaoko. Kubvisa, kuwedzera, uye kuona zvinhu zvinongoerekana zvaitika, zvichideredza nguva yekushanda uye kukanganisa kwevanhu. -
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Kuti uwane rumwe ruzivo:
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Nguva yekutumira: Nyamavhuvhu-12-2025