Kuongororwa Kwakakosha kweBCR-ABL pakurapa CML

Chirwere chemyelogenousleukemia (CML) chirwere chemasero eropa anokonzera kenza. Vanopfuura 95% vevarwere veCML vane Philadelphia chromosome (Ph) mumasero avo eropa. Uye gene reBCR-ABL fusion rinoumbwa nekuchinjana pakati peABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) paruoko rurefu rwechromosome 9 (9q34) uye gene reBCR region (BCR) paruoko rurefu rwechromosome 22 (22q11). Puroteni yayo yefusion inonyorwa negene iri ine tyrosine kinase (TK) activity, uye inomutsa nzira dzayo dzekutumira zviratidzo (dzakadai seRAS, PI3K, uye JAK/STAT) kukurudzira kupatsanurwa kwemasero uye kudzivirira apoptosis yemasero, zvichiita kuti masero awedzere zvakanyanya, uye nokudaro zvichikonzera kuitika kweCML.

Jini reBCR-ABL fusion, iro rakakosha mukukura kweCML, rinoshanda sechiratidzo chikuru chekuongorora. Kuonekwa kwayo kunobatsira kutarisa murwere'mhinduro ye tyrosine kinase inhibitors (TKIs) uye inofanotaura kudzoka kweleukemia, izvo zvakakosha pakutarisira varwere veCML zvinobudirira.

BCR-ABL yemunhuKiti Yekuona Kuchinja Kwemajini Emusanganiswakubva kuMacro & Micro-Test kuti vaone BCR-ABL muvarwere veCML, inobatsira kuongororwa kweCML uye inotungamira kurapwa kwakanangana nekiriniki kugadzirisa nzira dzekurapa kuti varwere vabatsirwe zvakanaka. BCR-ABL fusion gene, iyoirikukoshamukuvandudzwa kweCML,inoshanda sechiratidzo chikuru chekuongororaofCMLKuonekwa kwayo kunobatsiramonitorimurwere'smhinduro kune tyrosine kinase inhibitors (TKIs)uyeinofanotaura kudzoka kweleukemia, izvozvakakoshato inoshandaCMLkutarisira varwere.

Kiti yeKuona Kuchinja Kwemajini eBCR-ABL yeHuman BCR-ABL kubva kuMacro & Micro-Test kuti vaone kana BCR-ABL ine hunhu hwakanaka muvarwere vane CML., rubatsiroCMLkuongororwa kweropauyevatungamiririkurapwa kwakanangwatooptimizenzira dzekurapa dzekutarisira varwere zvinobudirira.

ZvakakwanaDkuedzwa:Panguva imwe chetekuonekwaye3majini akajairika ekubatanidza (P210, P190, P230)yekufukidzwa kwakakura uyekudzivirira kubva kumatambudziko asina kubatwa;

Kunzwa Kwakanyanya:Shanduro yemvura iyi inoona majini ekubatanidzaneLoDyemakopi 1000/mL,uye shanduro yakasanganiswaof Makopi mazana mashanu pa mL;

ZvakanakisaAkururama: Izvemukatikutongauye enzyme yeUNG kudzivirira zviratidzo zvenhema& zvakaipa;

Kushanda Zviri Nyore uye Kubudirira:Kushanda kwechubhu yakavharwa,isina zvigadzirwamushure mekugadzirisa,uyekuonekwamukatiMaminetsi makumi matanhatuyemhedzisiro chaiyo uye yakavimbika;

ZvimweSarudzo：Mhando dzemvura uye dzakapfava dzesarudzo dzevatengi;

Kuenderana Kwakakura:Inoenderana nemasisitimu mazhinji ePCR kuti ikwanise kushandiswa murabhoritari yakawanda.