Yakakosha BCR-ABL Kuonekwa kweCML Kurapa

Chronic myelogenousleukemia (CML) chirwere chakashata chechirwere chehematopoietic stem masero. Vanopfuura 95% yevarwere veCML vanotakura Philadelphia chromosome (Ph) mumasero avo eropa. Uye iyo BCR-ABL fusion gene inoumbwa nekuchinjika pakati peABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) paruoko rurefu rwechromosome 9 (9q34) uye breakpoint cluster region (BCR) gene paruwoko rurefu rwechromosome 212 (22q12). Protein yayo yefusion yakavharwa neiyi gene ine tyrosine kinase (TK) chiitiko, uye inomisa yayo yakadzika masaini nzira (yakadai seRAS, PI3K, uye JAK/STAT) kusimudzira kupatsanurwa kwesero uye inhibit cell apoptosis, zvichiita kuti masero awedzere zvakashata, uye nekudaro zvichikonzera kuitika kweCML.

BCR-ABL fusion gene, iyo yakakosha mukuvandudzwa kweCML, inoshanda sekiyi yekuongorora chiratidzo. zve CML. Kuonekwa kwayo kunobatsira kutarisa murwere's mhinduro kune tyrosine kinase inhibitors (TKIs) uye inofanotaura kudzoka kweleukemia, iyo inokosha pakubudirira kwehutano hweCML.

Munhu BCR-ABLFusion Gene Mutation Detection Kitkubva kuMacro & Micro-Test yekuonekwa kwemhando yeBCR-ABL muvarwere veCML, inobatsira CML kuongororwa uye kutungamira kwakanangwa kurapwa kwekiriniki kukwidziridza nzira dzekurapa dzehutano hwevarwere hunoshanda.BCR-ABL fusion gene, izvondizvozvakakoshamukuvandudza CML,inoshanda sechinhu chakakosha chekuongorora chiratidzoofCML. Kuonekwa kwayo kunobatsiramonitormurwere'smhinduro kune tyrosine kinase inhibitors (TKIs)uyeinofanotaura kudzoka kweleukemia, izvozvakakoshato inoshandaCMLkutarisira murwere.

Munhu BCR-ABL Fusion Gene Mutation Detection Kit kubva kuMacro & Micro-Test yekuonekwa kwemhando yeBCR-ABL muvarwere veCML, inobatsiraCMLkuongororwauyeguideskwakanangwa kurapwa kwekirinikitooptimizenzira dzokurapa dzehutano hwevarwere hunobudirira.

ComprehensiveDetection:Panguva imwe chetekuonekwanokuti3zvakajairika fusion majini (P210, P190, P230)nokutikufukidzwa kwakafara uyekudzivirira kubva kumatambudziko akapotsa;

High Sensitivity:Iyo liquid vhezheni inoona fusion majinipamwe neLoDye1000 makopi / mL,uye iyo lyophilized versionof 500 makopi / mL;

ExcellentAkururama: Internalcontroluye UNG enzyme kudzivirira maitiro enhema&negatives;

Nyore Kushanda uye Kubudirira:Yakavharwa-chubhu oparesheni,pasina zvigadzirwapost-processing,uyekuonekwamukati60 maminitsinokutichinangwa uye mhedzisiro yakavimbika;

ZvimweOptions:Liquid uye lyophilized shanduro dzesarudzo dzevatengi;

Wide Compatibility:Inoenderana neakawanda PCR masisitimu ekuwanikwa kwerabhoritari yakakura.