Kuonekwa kwemRNA yerudzi rwe15-HR-HPV - Kunoziva Kuvapo uye KUSHANDA kweHR-HPV

Gomarara remuchibereko, iro riri kukonzera kufa kwevakadzi pasi rose, rinonyanya kukonzerwa nehutachiona hweHPV. Kugona kwehutachiona hweHR-HPV kukonzera kenza kunoenderana nekuwedzera kwezviratidzo zvemajini eE6 neE7. Mapuroteni eE6 neE7 anosunga mapuroteni ep53 nepRb zvichiteerana, uye anotungamira kuwanda nekushanduka kwemasero emuchibereko.

Zvisinei, kuongororwa kweHPV DNA kunosimbisa kuvapo kwehutachiona, hakuoneki pakati pehutachiona hwakavanda uye huri kushandura hutachiona. Kusiyana neizvi, kuonekwa kwezvinyorwa zveHPV E6/E7 mRNA kunoshanda sechiratidzo chakajeka chekutaura kwehutachiona hunoshanda, uye nokudaro, inzira chaiyo yekufanotaura kenza yemudumbu (cervical intraepithelial neoplasia) (CIN) kana kuti carcinoma inopararira.

HPV E6/E7 mRNAKuongororwa kwegomarara remumuromo wechibereko kunopa zvakanakira zvikuru mukudzivirira gomarara remumuromo wechibereko:

• Kuongorora Njodzi Kwakarurama: Kunoongorora hutachiona hweHPV hune njodzi huru, zvichipa kuongororwa kwakanyatsojeka kwenjodzi kupfuura kuongororwa kweHPV DNA.
• Kuongororwa Kunoshanda: Kunopa mazano kuvanachiremba mukuona varwere vanoda kuongororwa kwakawanda, zvichideredza maitiro asina basa.
• Chishandiso Chingangoshandiswa Pakuongorora: Chinogona kushandiswa pakuongorora wega mune ramangwana, kunyanya kune vanhu vane njodzi huru.
• Mhando gumi neshanu dzeHuman Papillomavirus E6/E7 Gene mRNA Detection Kit (Fluorescence PCR) kubva ku #MMT, zvichiratidza chiratidzo chehutachiona hunogona kuramba huchienderera mberi hweHR-HPV, chishandiso chinobatsira pakuongorora HPV uye/kana kutarisira varwere.

Zvimiro zvechigadzirwa:

• Kufukidzwa kwakazara: Mhando gumi neshanu dzeHR-HPV dzine chekuita nekenza yemumuromo wechibereko dzakafukidzwa;
• Kunzwa kwakanaka kwazvo: 500 makopi/mL;
• Kunaka kwepamusoro: Hapana kusangana kwemasero emuropa ne cytomegalovirus, HSV II uye human genomic DNA;
• Kuchengetedza mari: Kuongororwa kunonyanya kuenderana nechirwere chinogona kuitika, kuderedza kuongororwa kusingakoshi nemari yekuwedzera;
• Kunyatsorongeka: IC yemaitiro ese;
• Kuenderana kwakafara: Nemasisitimu makuru ePCR;