Human Cytomegalovirus (HCMV) Nucleic Acid

Human cytomegalovirus (HCMV) inhengo ine genome yakakura kwazvo mumhuri yeherpes virus uye inogona kunyora mapuroteni anopfuura 200. HCMV yakaganhurirwa zvishoma kubva kuvanhu, uye hapana mhando yehutachiona hwemhuka. HCMV ine kutenderera kunononoka uye kwenguva refu kwekuumba muviri wekubatanidzwa mukati menyukiliya, uye inokonzera kugadzirwa kwemiviri ye perinuclear ne cytoplasmic inclusion uye kuzvimba kwemasero (mahombe masero), ndosaka zita racho richinzi. Zvichienderana nekusiyana kwe genome yayo ne phenotype, HCMV inogona kukamurwa kuita mhando dzakasiyana dzemarudzi, pakati payo pane mamwe marudzi akasiyana-siyana e antigenic, ayo, zvisinei, asina kukosha kwekiriniki.

Utachiona hweHCMV chirwere chinopararira mumuviri wese, chinosanganisira nhengo dzakawanda, chine zviratidzo zvakaoma uye zvakasiyana-siyana, chinowanzova chisiri chenguva dzose, uye chinogona kukonzera kuti varwere vashoma vabatwe nemaronda enhengo dzakawanda anosanganisira retinitis, hepatitis, pneumonia, encephalitis, colitis, monocytosis, uye thrombocytopenic purpura. Utachiona hweHCMV hwakajairika uye hunoita sekunge hwakapararira pasi rese. Hunowanikwa zvakanyanya muvanhu, nehuwandu hwekuwanda kwe45-50% uye hunopfuura 90% munyika dzakabudirira nedziri kusimukira, zvichiteerana. HCMV inogona kugara mumuviri kwenguva yakareba. Kana dziviriro yemuviri yadzikira, hutachiona huchatanga kushanda kuti hukonzere zvirwere, kunyanya hutachiona hunodzokororwa muvarwere vane leukemia nevarwere vanoisirwa nhengo, uye hunogona kukonzera necrosis yenhengo dzakaisirwa uye kuisa hupenyu hwevarwere muzviitiko zvakakomba. Pamusoro pekuzvarwa kwemwana akafa, kupererwa nepamuviri uye kusununguka nguva isati yakwana kuburikidza nehutachiona hwemukati mechibereko, cytomegalovirus inogonawo kukonzera malformations ekuzvarwa, saka hutachiona hweHCMV hunokwanisa kukanganisa kutarisirwa kwemwana asati azvarwa uye mushure mekusununguka uye hunhu hwevanhu.