Clostridium Difficile Glutamate Dehydrogenase(GDH) uye Toxin A/B

Clostridium difficile (CD) inosungirwa anaerobic gram-positive bacillus, inova maruva akajairika mumuviri wemunhu. Mamwe maruva anozodziviswa kuwanda nekuda kwemishonga inorwisa mabhakitiriya inoshandiswa muhukuru, uye CD inobereka mumuviri wemunhu muhuwandu hukuru. CD yakakamurwa kuva marudzi anogadzira chepfu uye asingabudisi muchetura. Ese maCD marudzi anogadzira glutamate dehydrogenase (GDH) kana abereka, uye chete toxigenic strains ndiyo pathogenic. Mishonga inobudisa chepfu inogona kubudisa chepfu mbiri, A uye B. Chepfu A inonzi enterotoxin, iyo inogona kukonzera kuputika kwemadziro emukati, kupinda kwesero, kuwedzera kwekudzivirira kwemadziro emukati, kubuda ropa uye necrosis. Toxin B inonzi cytotoxin, inokuvadza cytoskeleton, inokonzera sero pyknosis uye necrosis, uye inokuvadza zvakananga masero ematumbo emukati, zvichiita kuti manyoka uye pseudomembranous colitis.