Clostridium Difficile Glutamate Dehydrogenase (GDH) uye Toxin A/B

Clostridium difficile (CD) ibhakitiriya inosungirwa isina aerobic gram-positive, inova maruva akajairika mumuviri wemunhu. Mimwe maruva inodziviswa kuwanda nekuda kwemishonga inorwisa mabhakitiriya inoshandiswa muhuwandu hwakawanda, uye CD inobereka mumuviri wemunhu yakawanda. CD yakakamurwa kuva mhando dzinogadzira chepfu nedzisingaburitse chepfu. Mhando dzese dzeCD dzinogadzira glutamate dehydrogenase (GDH) padzinobereka, uye mhando dzetoxin chete ndidzo dzinokonzera hutachiona. Mhando dzinogadzira chepfu dzinogona kugadzira chepfu mbiri, A naB. Toxin A i enterotoxin, inogona kukonzera kuzvimba kwemadziro emudumbu, kupinda kwemasero, kuwedzera kupenya kwemadziro emudumbu, kubuda ropa uye necrosis. Toxin B i cytotoxin, inokuvadza cytoskeleton, inokonzera pyknosis yemasero ne necrosis, uye inokuvadza zvakananga masero emudumbu, zvichikonzera manyoka uye pseudomembranous colitis.