Chivabvu 17, 2023 izuva rechi19 "World Hypertension Day".
Hypertension inozivikanwa se "muurayi" wehutano hwevanhu.Inopfuura hafu yezvirwere zvemwoyo, sitiroko uye kutadza kwemoyo kunokonzerwa nehypertension.Naizvozvo, tichine nzira refu yekuenda mukudzivirira uye kurapwa kwehypertension.
01 Kupararira kwepasi rose kwehypertension
Munyika yose, vanhu vakuru vanosvika mabhiriyoni 1.28 vane makore 30-79 vane BP.Chete 42% yevarwere vane hypertension vanoonekwa uye vanorapwa, uye vangangoita mumwe muvashanu varwere vane hypertension yavo iri pasi pesimba.Muna 2019, huwandu hwevanhu vakafa nekuda kweBP pasi rose hwakapfuura mamirioni gumi, zvichitora chikamu chegumi nepfumbamwe muzana chevakafa vese.
02 Chii chinonzi Hypertension?
Hypertension chirwere chemoyo chemoyo chinoratidzwa nekuramba kuchiwedzera kuwedzera kweropa mumidziyo yeropa.
Varwere vazhinji havana zviratidzo zviri pachena kana zviratidzo.Nhamba shoma yevarwere vane hypertension inogona kuva nedzungu, kuneta kana kubuda ropa mumhino.Vamwe varwere vane systolic blood pressure ye200mmHg kana pamusoro vanogona kunge vasina zviratidzo zvekiriniki zviri pachena, asi mwoyo yavo, uropi, itsvo uye tsinga dzeropa zvakakuvadzwa kusvika kumwero wakati.Sezvo chirwere ichi chichifambira mberi, zvirwere zvinotyisidzira upenyu zvakadai sokukundikana kwemoyo, myocardial infarction, cerebral hemorrhage, cerebral infarction, renal insufficiency, uremia, uye peripheral vascular occlusion zvichazoitika.
(1) Yakakosha hypertension: inoverengera nezve 90-95% yevarwere vane hypertension.Inogona kunge yakabatana nezvinhu zvakawanda senge genetic factor, mararamiro, kufutisa, kushushikana uye zera.
(2) Sekondari hypertension: inoverengera nezve 5-10% yevarwere vane hypertension.Iko kuwedzera kweropa kunokonzerwa nezvimwe zvirwere kana zvinodhaka, zvakadai sechirwere chetsvo, endocrine kusagadzikana, chirwere chemwoyo, zvinodhaka zvinodhaka, nezvimwewo.
03 Kurapa kwezvinodhaka kune varwere vane hypertensive
Mitemo yekurapa hypertension ndeiyi: kutora mushonga kwenguva yakareba, kudzora chiyero cheBP, kuvandudza zviratidzo, kudzivirira uye kudzora matambudziko, etc. Matanho ekurapa anosanganisira kuvandudzwa kwemararamiro, kudzora kwega kwega kweropa, uye kutonga kwemoyo wemoyo ngozi zvinhu, pakati pazvo. kushandiswa kwenguva refu kwemishonga inorwisa-hypertensive ndiyo inonyanya kukosha yekurapa.
Vanachiremba vanowanzo sarudza musanganiswa wemishonga yakasiyana zvichienderana nehuwandu hweBP uye nengozi yemwoyo yemurwere, uye kusanganisa kurapwa kwezvinodhaka kuti vabudirire kutonga kweropa.Mishonga inorwisa hypertensive inowanzoshandiswa nevarwere inosanganisira angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), β-blockers, calcium channel blockers (CCB), uye diuretics.
04 Kuongororwa kweGenetic yekushandiswa kwezvinodhaka kune varwere vane hypertension
Parizvino, mishonga yeantihypertensive inogara ichishandiswa mumakiriniki kazhinji ine misiyano yega yega, uye kurapa kwemishonga yehypertension inodyidzana zvakanyanya neiyo genetic polymorphisms.Pharmacogenomics inogona kujekesa hukama pakati pemhinduro yemunhu kune zvinodhaka uye genetic variation, senge kurapa maitiro, dosage level uye akashata maitiro anomirira.Vanachiremba vanozivisa zvinangwa zvemajini zvinosanganisirwa mukudzorwa kweBP muvarwere vanogona kubatsira kuenzanisa mishonga.
Naizvozvo, kucherechedzwa kwemishonga ine chekuita nejini polymorphisms inogona kupa humbowo hwakakodzera hwemajini kune kusarudzwa kwekiriniki yemhando dzezvinodhaka zvinodhaka uye madhiziri ezvinodhaka, nekuvandudza kuchengetedzwa uye kushanda kwekushandisa zvinodhaka.
05 Hunoshanda huwandu hwekuongorora genetic yemushonga wega wega wehypertension
(1) Varwere vane hypertension
(2) Vanhu vane nhoroondo yemhuri yeBP
(3) Vanhu vakambobatwa nezvinodhaka zvisina kunaka
(4) Vanhu vane hurombo hwekurapa zvinodhaka
(5) Vanhu vanoda kutora mishonga yakawanda panguva imwe chete
06 Mhinduro
Macro & Micro-Test yakagadzira akawanda fluorescence ekuona makiti ekutungamira uye kuonekwa kwemishonga yehypertension, ichipa mhinduro yakazara uye yakazara yekutungamira mishonga yekiriniki yega yega uye kuongorora njodzi yezvakakomba zvinodhaka zvinodhaka:
Chigadzirwa chacho chinogona kuona 8 gene loci ine chekuita nemishonga inorwisa-hypertensive uye inoenderana ne5 makirasi makuru emishonga (B adrenergic receptor blockers, angiotensin II receptor antagonists, angiotensin inoshandura enzyme inhibitors, Calcium antagonists uye diuretics), chishandiso chakakosha chinogona kutungamira mishonga yekiriniki yega. uye kuongorora njodzi yezvakakomba zvakashata zvezvinodhaka.Nekuona ma enzymes ekugadzirisa zvinodhaka uye majini anonangwa nemishonga, varapi vanogona kutungamirwa kuti vasarudze zvinodhaka zveantihypertensive uye dosage yevarwere chaivo, nekuvandudza kushanda uye kuchengetedzeka kwemishonga inorwisa BP.
Easy kushandisa: uchishandisa melting curve tekinoroji, 2 reaction matsime anogona kuona 8 masaiti.
Kunzwa kwakanyanya: iyo yakaderera yekuona muganho ndeye 10.0ng/μL.
High kururama: Zvose zvezvikamu zve60 zvakaedzwa, uye nzvimbo dzeSNP dzejini imwe neimwe dzaive dzakaenderana nemigumisiro yechizvarwa chinotevera kana chizvarwa chekutanga, uye chiyero chekubudirira kwekutsvaga chaiva 100%.
Zvakavimbika: yemukati mwero yemhando yekudzora inogona kutarisa iyo yese yekuona maitiro.
Nguva yekutumira: May-17-2023