Ongororo yemetagenomic ichangobva kuitwa yakaratidza huwandu hwakasiyana-siyana hwemavhairasi nemabhakitiriya anotakurwa nemakonzo muHeilongjiang Province, kusanganisira Lassa virus, Amur virus, Salmonella, uye Yersinia pestis.
Tsvagiridzo iyi yakashandisaKiti yekuvandudza RNA kubva kuMacro & Micro-Test, zvichibva pahunyanzvi hwekubata probe. Nekusarudza kubvisa host rRNA nezvimwe zvidimbu zvehost zvakachengetedzwa, nzira iyi yakachengetedza RNA yehutachiona zvinobudirira, zvichivandudza zvakanyanya kunzwisisika kwekuona hutachiona. Danho iri rekuwedzera RNA yehutachiona raive rakakosha mukuwana chiyero chepamusoro chekuona uye rakapa rutsigiro rwakasimba rwehunyanzvi hwekutarisa hutachiona.
Makonzo: Nzvimbo Dzinokosha Dzekudzivirira Zvirwere zveZoonotic
Makonzo ndiwo boka remhuka dzinoyamwisa dzakapfuma uye dzakapararira zvakanyanya, riine marudzi anopfuura 2,000 pasi rose uye rinoita anopfuura 40% yemarudzi ese emhuka dzinoyamwisa.
Kunze kwekukosha kwadzo kune zvakatipoteredza, makonzo anoshanda senzvimbo huru dzekuchengetedza uye senzira yekudzivirira zvirwere zvakasiyana-siyana zvinotapukira kubva kumhuka.Nekuti nzvimbo dzinogara makonzo dzinowanzo sangana nenzvimbo dzevanhu—kuburikidza nekurumwa zvakananga, kusangana netsvina, kana kutapurirana zvisina kunanga kuburikidza nenhata nezvipembenene—utachiona hwadzinogara hunoramba huchityisidzira hutano hwevanhu.
Zvinonyanya kukosha kuti, anopfuura 70% ezvirwere zvinotapukira zvinobva kumhuka dzesango, nemakonzo achimiririra imwe yenzvimbo dzinonyanya kupararira mavhairasi.
Dunhu reHeilongjiang Border: Mutsetse weKutarisa Utachiona
Heilongjiang, dunhu riri pamuganhu kuchamhembe kwakadziva kumabvazuva kweChina, rine zviwanikwa zvakawanda zvezvakatipoteredza uye rine miganhu nenyika dzakawanda. Kusanganiswa kwemarudzi akasiyana-siyana ezvisikwa uye kufamba-famba kwevanhu vakawanda vachiyambuka miganhu kunoita kuti pave nemamiriro akanaka ekutapurirana kwezvirwere.
Pakati paChikumi naChikunguru 2021, vaongorori vakaunganidza makonzo emusango makumi matanhatu nenomwe kubva kuHengdaohezi Town, Muguta reMudanjiang. Mienzaniso yacho yaisanganisira:
l 20Apodemus peninsulae
l 47Myodes rufocanus
Mienzaniso yese yakatorwa munzvimbo dzekugara nevanhu nenzvimbo dzekurima dzakapoteredza, zvichiratidza kubatana kuripo pakati penzvimbo dzekugara kwevanhu nenzvimbo dzemhuka dzesango.
Tekinoroji Yekuvandudza Utachiona: Kukunda Kupindira Kwemamiriro Ekunze Kwemunhu Anogamuchira Utachiona
Mukuongorora metagenomic sequencing, host RNA inowanzo tarisa sequencing reads, ichivhara zviratidzo zvehutachiona husina kuwanda.
Kuti vagadzirise dambudziko iri, chidzidzo ichi chakashandisaKiti yeKuongorora Metagenomic yeMacro & Micro-Test. Zvichishandisa tekinoroji yekubata mapurobe, mapurobe akagadzirwa zvakananga anosunga kune rRNA inogarwa uye anochengetedza marongerwo, zvichiita kuti apere uye nokudaro achivandudza RNA yemabhakitiriya.
Maitiro aya akavandudza zvakanyanya kunzwisiswa kwehutachiona, zvichibvumira kutevedzana kwezvirwere kuti zviwane huwandu hwakawanda hwehutachiona. Danho rekuwedzera rakaisa hwaro hwakasimba hwekutsanangura nemazvo huwandu hwehutachiona hunotakurwa nemakonzo.
Mushure mekuwedzerwa kweruzivo, RNA samples dzakaitwa reverse transcription, rakagadzirwa muraibhurari, uye high-throughput sequencing. Ongororo ye bioinformatic yakabatanidza:
l Kusefa kwe genome yeHost
Kupatsanura Taxonomic uchishandisa Kraken2
l Kugadziriswa kwakawanda neBracken
Kufambiswa kwebasa uku kwakagadzira ruzivo rwakakwana rwenharaunda dzemavhairasi nemabhakitiriya.
Zvakawanikwa paKutsvagurudza: Kupararira pamwe chete kweMavhairasi neMabhakitiriya akawanda
Zvakawanikwa nehutachiona
Mavhairasi akawanikwa aive emhuri makumi maviri nerimwe dzemavhairasi, kusanganisiraArenaviridaeuyeHantaviridae.
Kuburikidzade novoKugadzira nekushandisa Megahit, mavhairasi 154 akagadzirwa, uye 110 acho akabatana nemavhairasi 19 kubva kumhuri sere.
In Apodemus peninsulae, mavhairasi anotevera akaonekwa:
l Arenaviruses: Lassa virus, Wenzhou virus, Gairo virus
l Hantaviruses: Amur virus, Puumala virus
In Myodes rufocanus, Makonzo arterivirus neAmur virus zvakaonekwa.
Pakati pezvirwere izvi:
l Utachiona hweLassa hunokonzera fivha inobuda ropa, uye huwandu hwevakafa hunosvika 20%.
l Utachiona hweAmur ndechimwe chezvirwere zvinokonzera fivha yeropa ine chirwere cheitsvo (HFRS). China inotaura kuti ine mutoro mukuru wehutachiona hwehantavirus pasi rose.
Zvakawanikwa neMabhakitiriya
Marudzi ebhakitiriya anosvika 1,051 akatsanangurwa.
Marudzi akawandisa aive:
lSalmonella(26–31%)
lYersinia(11–23%)
Salmonellaihosha huru inokonzerwa nechikafu, iyo inokonzera nyaya dzinofungidzirwa kuti dzinenge mamiriyoni mapfumbamwe dzefivha yetyphoid uye vanhu vanosvika zviuru zana negumi vanofa gore rega rega pasi rose.
Yersinia pestis, chinokonzera denda, chave chiri kukonzera zvirwere zvitatu zvekare. Dunhu reHeilongjiang rinozivikanwa seimwe yenzvimbo dzeChina dzinonyanya kukonzera denda uye richiri nzvimbo inonyanya kukosheswa pakuongorora denda.
Kukosha kweChidzidzo
Mipiro yeSainzi
Chidzidzo ichi chinomiririra mushumo wekutanga wezvidimbu zvehutachiona hweLassa nehutachiona hwe arteritis yemakonzo mumakonzo anobva kuHeilongjiang, zvichiwedzera dhatabhesi rehutachiona hwemakonzo muChina.
Inoronga nharaunda dzemavhairasi nemabhakitiriya munzvimbo dzemakonzo emunharaunda, ichipa ruzivo rwekutanga rwekutarisa zvirwere zvemhuka munzvimbo dziri pamuganhu.
Zvinokonzera Hutano Hweveruzhinji
Zvakawanikwa zvinoratidza kukosha kwekutarisa nguva dzose uye kuongororwa kwezvirwere zvinotapukiraA. PeninsulaeuyeM. rufocanus.
Ruzivo urwu runopa humbowo hwesainzi hunotsigira nzira dzekudzora zvirwere zvakaita sedenda nefivha inobuda ropa ine chirwere cheitsvo.
Simba reMaitiro
Kutevedzana kwemetagenomic kunoita kuti pave neruzivo rwakakwana rwezvirwere zvinozivikanwa nezvitsva.
Muchidzidzo ichi, tekinoroji yekuvandudza utachiona yeMacro & Micro-Test yakaratidza kushanda kwakasimba, ichivandudza kuwanikwa kwehutachiona hwakanangana nemhuka dzakaoma. Zvakabuda zvinoratidza kugona kwayo kutsigira kuzivikanwa kwehutachiona hwakasimba mukuongorora mhuka dzesango.
Kurudziro yeChigadzirwa
Zvichibva pakubudirira kwayo mukudzidza uku, Macro & Micro-Test Pathogen RNA Enrichment Kit inokurudzirwa zvikuru pakutsvaga metagenomic surveillance.
Nekubvisa zvinobudirira nucleic acids yemutumbi uye kuwedzera hutachiona, kit iyi inovandudza zvakanyanya kunzwisiswa kwehutachiona uye kunaka kwedata. Inomiririra chishandiso chakakosha chekuwana utachiona nemazvo mumasampuli akaomarara uye inopa rutsigiro rwakasimba rwehunyanzvi hwekutarisa hutano hweveruzhinji, kuongorora njodzi yemhuka, uye kugadzirira kubuda kwechirwere.
Contact to learn more: marketing@mmtest.com
Nguva yekutumira: Kurume-02-2026