Kuchinja kwemapoinzi mujini reKRAS kunobatanidzwa mumhando dzakasiyana dzemabundu evanhu, nehuwandu hwekuchinja hunosvika 17%–25% mumhando dzebundu, 15%–30% mukenza yemapapu, uye 20%–50% mukenza yemudumbu. Kuchinja uku kunotungamira kuramba kurapwa uye kufambira mberi kwebundu kuburikidza nenzira yakakosha: puroteni yeP21 inokopwa neKRAS inoshanda pasi penzira yekutumira zviratidzo yeEGFR. Kana KRAS yangochinja, inogara ichimutsa kutumira zviratidzo pasi, zvichiita kuti kurapwa kweEGFR-target kunange kusashande uye zvichikonzera kuwanda kwemasero ane malignant. Nekuda kweizvozvo, kuchinja kweKRAS kwakabatana nekuramba kudzivirira EGFR tyrosine kinase inhibitors mukenza yemapapu uye kurapwa kwe-anti-EGFR antibody mukenza yemudumbu.

Muna 2008, National Comprehensive Cancer Network (NCCN) yakagadzira nhungamiro dzekiriniki dzinokurudzira kuongororwa kweKRAS mutation kune varwere vese vane metastatic colorectal cancer (mCRC) vasati varapwa. Mitemo iyi inoratidza kuti ruzhinji rweKRAS mutations dzinoshanda dzinoitika mumacodon 12 ne13 eexon 2. Saka, kukurumidza uye kwakarurama kuona KRAS mutation kwakakosha pakutungamira kurapwa kwakakodzera.

Nei Kuongororwa kweKRAS Kwakakosha MuMkutapukiraColorectalCkenza(mCRC)

Kenza yemudumbu (CRC) haisi chirwere chimwe chete asi muunganidzwa wemhando dzakasiyana dzemamorekuru. Kuchinja kweKRAS—kuripo muvanhu vanosvika 40–45% vevarwere veCRC—kunoshanda se "on" switch inogara iripo, zvichikurudzira kukura kwekenza pasina zviratidzo zvekunze. Kune varwere vane mCRC, mamiriro eKRAS anosarudza kushanda kwema antibodies ekudzivirira EGFR monoclonal akadai seCetuximab nePanitumumab:

KRAS yemhando yemusango:Varwere vangangobatsirwa nekurapwa kwekudzivirira EGFR.

KRAS Yakachinja:Varwere havabatsirike nemishonga iyi, zvichikonzera matambudziko asina basa, mitengo yakakwira, uye kunonoka kwekurapwa kunoshanda.

Kuongororwa kweKRAS kwakarurama uye kwakanyatsojeka saka ndiyo nheyo yekuronga kurapwa kwakagadzirirwa munhu wega.

Dambudziko reKuona: Kusiyanisa Chiratidzo cheKuchinja

Nzira dzechinyakare dzinowanzo shaya kunzwa kwekuchinja kwakawanda, kunyanya mumienzaniso ine bundu shoma kana mushure mekubviswa kwecalcium mumasero. Dambudziko riri pakusiyanisa chiratidzo cheDNA chisina kusimba chichienzaniswa nechimiro chemusango chakakwirira—sekuwana tsono muhuswa. Mhedzisiro isiriyo inogona kutungamira mukurapwa kusina ruzivo uye mhedzisiro yacho inogona kukanganiswa.

Mhinduro Yedu: Yakagadzirwa Neunyanzvi Hwakanaka Kuti Ione Kuchinja Kwemuviri Kune Musoro

Kiti yedu yeKRAS Mutation Detection Kit inobatanidza matekinoroji epamusoro kuti ikunde zvipingamupinyi izvi, ichipa kururama kwakanyanya uye kuvimbika kwenhungamiro yekurapa kwemCRC.

Maitiro Ekuti Tekinoroji Yedu Inoita Kuti Ishande Zvakanaka

• Tekinoroji yeARMS Yakavandudzwa (Amplification Refractory Mutation System): Yakavakirwa patekinoroji yeARMS, ichisanganisira tekinoroji yekuwedzera simba rekuona kuti zvinhu zviri kushanda sei.
• Kuwedzerwa kweEnzymatic: Inoshandisa restriction endonucleases kugaya ruzhinji rwema genome emunhu, ichichengetedza marudzi emutant, nokudaro ichivandudza kugona kwekuona uye ichideredza kuwedzera kusingatarisirwi nekuda kwekuva ne genomic background yakakura.
• Kuvhara Tembiricha: Kunopa matanho chaiwo ekupisa muPCR, zvichikonzera kusawirirana pakati pema "mutant primers" nema "wild-type templates", nokudaro zvichideredza mamiriro e "wild-type" uye kuvandudza kugona kuona.
• Kunzwa Kwakanyanya: Inoona nemazvo DNA yakachinja ine 1% yemasero.
• Kururama Kwakanaka: Inoshandisa zviyero zvemukati uye enzyme yeUNG kudzivirira mhedzisiro yenhema yakanaka neisina kunaka.
• Zviri Nyore uye Zvinokurumidza: Inopedza bvunzo mumaminitsi angangoita 120, ichishandisa machubhu maviri ekuita kuti zviite nyore kuona shanduko sere dzakasiyana, zvichipa mhedzisiro yakavimbika uye yakajeka.
• Kuenderana kwezviridzwa: Kunoenderana nezvishandiso zvakasiyana-siyana zvePCR.

Mushonga chaiwo wegomarara remudumbu unotanga nekuongorora kwakanyatsojeka kwemasero. Nekushandisa KRAS Mutation Detection Kit yedu, rabhoritari yenyu inogona kupa mhedzisiro chaiyo uye inoshanda iyo inoumba zvakananga nzira yekurapwa kwemurwere.

Simbisa rabhoritari yako netekinoroji yakavimbika uye yemazuva ano—uye ita kuti kutarisirwa kwakakodzera iwe pachako kuve kwako.

Taura nesu: kushambadzira@mmtest.Com

Dzidza zvakawanda nezvekubatanidza mhinduro iyi yepamusoro mukushanda kwako kwekuongorora.

#Kurapwa kweColorectal #Kenza #DNA #Kuchinja #Kururama #Kwakanangana #Kurapwa #Kenza

Kuvhura Mushonga Wakakodzera Mukenza yeColorectal

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