Mapoinzi shanduko muKRAS gene anosanganisirwa mumhando dzakasiyana dzemamota emunhu, aine huwandu hwekuchinja hunosvika 17% -25% pamhando dzemota, 15% -30% mukenza yemapapu, uye 20% -50% mugomarara reruvara. Idzi shanduko dzinofambisa kurapwa kuramba uye kufambira mberi kwebundu kuburikidza nekiyi nzira: iyo P21 protein yakavharidzirwa neKRAS inoshanda pasi penzira yeEGFR yekusaina. Kana KRAS ichinge yashandurwa, inogara ichiita siginecha yakadzika pasi, ichipa kukwira kweEGFR-yakanangwa marapirwo kusashanda uye zvichiita kuti masero arambe achiwedzera. Nekuda kweizvozvo, kuchinja kweKRAS kwakabatana nekupokana neEGFR tyrosine kinase inhibitors mukenza yemapapu uye kune anti-EGFR antibody kurapa mune colorectal cancer.

Muna 2008, National Comprehensive Cancer Network (NCCN) yakagadzira nhungamiro yekiriniki ichikurudzira kuongororwa kweKRAS mutation kune vese varwere vane metastatic colorectal cancer (mCRC) vasati varapwa. Nhungamiro dzinoratidza kuti ruzhinji rwekushandura KRAS kuchinja kunoitika mukodons 12 uye 13 ye exon 2. Nokudaro, nekukurumidza uye kwakarurama KRAS mutation yekuona inokosha pakutungamirira kurapa kwakakodzera kwekliniki.

Nei Kuongororwa kweKRAS Kwakakosha mukatiMetastaticColorectalCancer(mCRC)

Colorectal cancer (CRC) hachisi chirwere chimwe chete asi muunganidzwa wemamolecularly akasiyana subtypes. KRAS mutations-inowanikwa munenge 40-45% yevarwere veCRC-ita senge inogara "pa" switch, inokurudzira kukura kwegomarara pasina zviratidzo zvekunze. Kune varwere vane mCRC, chimiro cheKRAS chinotarisa kushanda kweanorwisa EGFR monoclonal antibodies seCetuximab uye Panitumumab:

Wild-Type KRAS:Varwere vangangobatsirwa neanti-EGFR kurapwa.

Mutant KRAS:Varwere havawani pundutso kubva kune ava vamiririri, vachiisa njodzi isina kufanira mhedzisiro, kuwedzera mitengo, uye kunonoka mukurapa kunoshanda.

Kwakaringana uye kunzwira tsitsi kuyedzwa kweKRAS saka ibwe repakona rekuronga kwemunhu kurapwa.

Dambudziko rekuona: Kusiyanisa Mutation Signal

Nzira dzechinyakare dzinowanzoshaikwa kunzwisiswa kwekuderera-kwakawanda shanduko, kunyanya mumasampuli ane yakaderera bundu zvemukati kana mushure mekuita decalcification. Chinetso chacho chiri pakusiyanisa chiratidzo cheDNA chinoshanduka-shanduka pane imwe nzvimbo yakakwirira-yakafanana nekutsvaga tsono munhokwe. Migumisiro isina kururama inogona kutungamirira kukurapa kusina ruzivo uye migumisiro yakakanganiswa.

Yedu Solution: Precision-Engineered for Confident Mutation Detection

Yedu KRAS Mutation Detection Kit inosanganisa matekinoroji epamberi kuti akunde zvipingamupinyi izvi, zvichiunza huchokwadi hunoshamisa uye kuvimbika kwekutungamira kwekurapa kwemCRC.

Iyo Tekinoroji Yedu Inosimbisa Kuita Kwepamusoro

• Yakavandudzwa tekinoroji yeARMS (Amplification Refractory Mutation System): Inovaka patekinoroji yeARMS, ichibatanidza tekinoroji yekusimudzira tekinoroji kuti iwedzere kutariswa.
• Enzymatic Enrichment: Inoshandisa zvirambidzo endonuclease kugaya ruzhinji rwevanhu genome yemusango-yemhando yekumashure, ichichengetedza mutant mhando, nekudaro inosimudzira kuoneswa uye kuderedza kusiri-chaiyo amplification nekuda kwepamusoro genomic kumashure.
• Kuvharira Tembiricha: Inosuma nhanho dzetembiricha muPCR maitiro, zvichikonzera kusawirirana pakati pemutant primers uye mhuka dzesango-matemplate, nekudaro ichidzikisa emusango-mhando yekumashure nekuvandudza kugadzirisa kwekuona.
• High Sensitivity: Inonyatsoona yakaderera se1% mutant DNA.
• Yakanyanya Kurongeka: Inoshandisa zviyero zvemukati uye UNG enzyme kudzivirira mhedzisiro yenhema uye yakaipa.
• Yakareruka uye Inokurumidza: Inopedza kuyedza mukati memaminitsi angangoita zana nemakumi maviri, ichishandisa machubhu maviri ekuita kufambisa kuonekwa kwemasere akasiyana ekuchinja, ichipa chinangwa uye mhedzisiro yakavimbika.
• Instrument Kuenderana: Inochinjika kune akasiyana PCR zviridzwa.

Mushonga chaiwo mune colorectal cancer unotanga nechaiyo molecular diagnostics. Nekutora KRAS Mutation Detection Kit yedu, rabhoritari yako inogona kuunza mhedzisiro, inogoneka inogadzirisa nzira yekurapa yemurwere.

Simbisa lab yako neakavimbika, yekucheka-kumucheto tekinoroji-uye gonesa kunyatsotarisirwa munhu.

Taura nesu: marketing@mmtest.Com

Dzidza zvakawanda nezvekubatanidza iyi mhinduro yepamusoro mune yako diagnostic workflow.

#Colorectal #Cancer #DNA #Mutation #Precision #Targeted #Kurapwa #Cancer

Kuvhura Precision Mushonga muColorectal Cancer

https://www.linkedin.com/posts/macro-micro-ivd_colorectal-cancer-dna-activity-7378358145812930560-X4MN?utm_source=share&utm_medium=member_desktop&rcm=ACoAADjGw3MBNMB2op5op5