Iyo Yakakosha Basa reBiomarker Kuedzwa muPamusoro Cancer Killer

Maererano neshumo ichangoburwa yegomarara repasi rose, gomarara remapapu rinoramba riri iro rinonyanya kukonzera kufa kwegomarara pasi rose, richitora chikamu che18.7% chevanhu vakafa vakadaro muna 2022. Ruzhinji rwezviitiko izvi ndiNon-Small Cell Lung Cancer (NSCLC). Nepo nhoroondo yekuvimba nechemotherapy yechirwere chepamusoro ichipa rubatsiro rushoma, iyo paradigm yakachinja zvakanyanya.

Kuwanikwa kweakakosha biomarkers, akadai seEGFR, ALK, uye ROS1, kwashandura marapirwo, achiafambisa kubva kune imwe-saizi-inokodzera-yese nzira kuenda kune chaiyo zano rinonangana neakasarudzika madhiraivha egomarara remurwere wega wega.

Nekudaro, kubudirira kweaya marapirwo echimurenga anoenderana zvachose nekwakaringana uye kwakavimbika genetic test kuona chinangwa chakakodzera chemurwere akakodzera.

Iwo Akakosha Biomarkers: EGFR, ALK, ROS1, uye KRAS

Ma biomarker mana anomira sembiru mukuongororwa kwema molecular yeNSCLC, achitungamira sarudzo dzekutanga dzekurapa:

-EGFR:Iyo inonyanya kuitika inogoneka shanduko, kunyanya muAsia, vakadzi, uye vasiri kuputa. EGFR tyrosine kinase inhibitors (TKIs) yakafanana neOsimertinib yakavandudza migumisiro yevarwere.

-ALK:Iyo "diamond mutation," iripo mu5-8% yeNSCLC kesi. ALK fusion-positive varwere vanowanzopindura zvakanyanya kune ALK inhibitors, vachiwana kurarama kwenguva refu.

-ROS1:Kugovera maitiro akafanana neALK, iyi "gem isingawanzo" inoitika mu1-2% yevarwere veNSCLC. Mishonga yakanangwa inoshanda iripo, zvichiita kuti kuonekwa kwayo kuve kwakakosha.

-KRAS:Nhoroondo yainzi "haigoneki," kuchinja kweKRAS kwakajairika. Mvumo ichangoburwa yeKRAS G12C inhibitors yakashandura iyi biomarker kubva kune prognostic marker kuita chinangwa chinoitwa, kusandura kutarisirwa kweiyi subset yemurwere.

Iyo MMT Portfolio: Yakagadzirirwa Diagnostic Confidence

Kuti isangane nechimbichimbi chekuzivikanwa kweiyo biomarker chaiyo, MMT inopa portfolio yeEC-IVD yakanyorwa chaiyo-nguva.PCR yekuona kits, imwe neimwe yakagadziridzwa neinocheka-kumucheto tekinoroji kuti ive nechokwadi chekuongorora kuvimba.

1. EGFR Mutation Detection Kit

-Yakavandudzwa ARMS Tekinoroji:Proprietary enhancers inowedzera mutation-yakananga amplification.

-Enzymatic Enrichment:Restriction endonucleases inogaya iyo yemusango-mhando genomic kumashure, inopfumisa mutant kutevedzana uye inosimudzira kugadzirisa.

-Kuvhara Tembiricha:Imwe nhanho yekupisa inoderedza isina-chaiyo priming, ichiwedzera kuderedza yemusango-mhando yekumashure.

-Mabhenefiti Akakosha:Kunzwa kusingaenzaniswi kusvika1%mutant allele frequency, kunyatso kurongeka nekutonga kwemukati uye UNG enzyme, uye nekukurumidza kutendeuka nguva yeanenge.120 maminitsi.

- Inopindirana nezvese zviri zviviri tishu uye mvura biopsy samples.

1. MMT EML4-ALK Fusion Detection Kit

- High Sensitivity:Inonyatsoona fusion mutations ine muganho wakaderera wekuonekwa kwe20 makopi / kuita.

-Kururama Kwakanaka:Inobatanidza zviyero zvemukati zvekugadzirisa maitiro uye UNG enzyme yekudzivirira kusvibiswa kwekutakura, kunyatsodzivisa zvisizvo zvenhema uye zvakashata.

-Zviri Nyore uye Nekukurumidza:Inoratidzira yakagadziridzwa, yakavharwa-chubhu oparesheni inopedzwa mukati memaminitsi angangoita zana nemakumi maviri.

-Kuenderana Nezviridzwa:Inochinjika kune dzakasiyana siyanachaiyo-nguva PCR zviridzwa, inopa kuchinjika kune chero kugadzwa kwerabhoritari.

1. MMT ROS1 Fusion Detection Kit

High Sensitivity:Inoratidza mashandiro anoshamisa nekuona zvakavimbika zvakaderera semakopi makumi maviri / maitiro ezvinangwa zvefusion.

Kururama Kwakanaka:Iko kushandiswa kwemukati mehutongi hwemhando uye UNG enzyme inova nechokwadi chekuvimbika kwechero mhedzisiro, kuderedza njodzi yekureva zvikanganiso.

Zviri Nyore uye Nekukurumidza:Seyakavharwa-chubhu system, haidi yakaoma post-amplification matanho. Zvinangwa uye zvakavimbika mhedzisiro inowanikwa muinenge 120 maminetsi.

Kuenderana Nezviridzwa:Yakagadzirirwa kufambirana kwakafara nemhando dzakasiyana dzePCR michina, kufambisa nyore kusanganisa mune iripo lab workflows.

1. MMT KRAS Mutation Detection Kit

- Yakavandudzwa tekinoroji yeARMS, yakasimbiswa neEnzymatic Enrichment uye Tembiricha Kuvharira.

- Enzymatic Enrichment:Inoshandisa kudzora endonucleases kugaya zvakasarudzika iyo yemusango-mhando genomic kumashure, nekudaro ichipfumisa mutant kutevedzana uye zvakanyanya kusimudzira kuonesa kugadziriswa.

-Kuvhara Tembiricha:Inosuma imwe tembiricha nhanho yekukurudzira kusawirirana pakati pemutant-chaiyo primers uye yemusango-mhando matemplate, ichiwedzera kudzikisira kumashure nekuvandudza hunhu.

- High Sensitivity:Inowana kunzwisiswa kwe1% kune mutant alleles, kuve nechokwadi chekuzivikanwa kweakaderera-akawanda shanduko.

-Kururama Kwakanaka:Yakabatanidzwa mukati meyero uye UNG enzyme chengetedza kubva kune enhema yakanaka uye yakaipa mhedzisiro.

-Comprehensive Panel:Yakagadziridzwa zvine hungwaru kuti ifambise kuwonekwa kwemasere akasiyana eKRAS mutations mumachubhu maviri ekuita.

- Zviri Nyore uye Nekukurumidza:Inopa chinangwa uye yakavimbika mhedzisiro mune angangoita 120 maminetsi.

- Kuenderana Nezviridzwa:Inochinjika zvisina musono kune akasiyana PCR zviridzwa, zvichipa kuita kwakasiyana-siyana kumakiriniki marabhoritari.

Sei Kusarudza MMT NSCLC Solution?

Yakakwana: Iyo yakazara sutu kune ina inonyanya kukosha NSCLC biomarkers.

Tekinoroji yepamusoro: Proprietary ekuwedzera (Enzymatic Enrichment, Tembiricha Kuvharika) inova nechokwadi chepamusoro uye kunzwisiswa pazvinonyanya kukosha.

Kurumidza & Kushanda: Uniform ~ 120-maminetsi protocol pane iyo portfolio inomhanyisa nguva-ku-kurapa.

Inochinjika & Inosvikika: Inoenderana neakasiyana siyana emhando dzemhando uye makuru ePCR zviridzwa, kuderedza zvipingamupinyi zvekushandisa.

Mhedziso

Munguva yeiyo chaiyo oncology, molecular diagnostics ndiyo kambasi inotungamira kurapa kwekufamba. Makitsi ekuongorora epamusoro eMMT anopa simba varapi kuti vatarise zvine chivimbo mamiriro erudzi rweNSCLC yemurwere, vachivhura mukana wekuponesa hupenyu hweanonangwa marapirwo.

Contact to learn more: marketing@mmtest.com