Gomarara remapapu richiri kukonzera kufa kwevanhu vakawanda pasi rose nekuda kwegomarara,Kenza yemapapu isiri diki (NSCLC) inoumba vanhu vanosvika 85% yezvirwere zvese.Kwemakumi emakore, kurapwa kweNSCLC yepamusoro kwainyanya kushandiswa pakurapa chemotherapy, mushonga usina simba rakawanda uye waive nengozi shoma.
Kuchinja kwekurapa kwakatanga nekuwanikwa kwe "kuchinja kwemutyairi" - shanduko dzemajini dzinokurudzira kukura kwegomarara. Izvi zvakakonzera kurapwa kwakanangana, kunoshanda semabhomba anotungamirirwa nemazvombo, zvichiparadza masero egomarara nenzira yakasarudzika ukuwo zvichichengetedza masero ane hutano. Zvisinei, kubudirira kwekurapa uku kwakachinja-chinja kunoenderana nekuongororwa kwemajini kwakarurama uye kwakavimbika kuti kuonekwe chinangwa chakakodzera chemurwere akakodzera.
Zviratidzo Zvinokosha zveBiomarkers: EGFR, ALK, ROS1, uye KRAS
Zviratidzo zvina zve biomarkers zvinomira senzvimbo huru mukuongororwa kwemamorekuru eNSCLC, zvichitungamira sarudzo dzekurapa dzemutsara wekutanga:
-EGFR:Kuchinja kwemuviri kunonyanya kushandiswa, kunyanya muvanhu vekuAsia, vakadzi, uye vasiri kuputa fodya. Mishonga yeEGFR tyrosine kinase inhibitors (TKIs) yakaita seOsimertinib yakavandudza zvikuru mhedzisiro yevarwere.
-ALK:"Kuchinja kwedhaimani," kunowanikwa mu5-8% yevanhu vane NSCLC. Varwere vane ALK fusion-positive vanowanzo pindura zvakanyanya kune vanodzivirira ALK, zvichiita kuti vararame kwenguva refu.
-ROS1:Kufanana kwemaumbirwo eALK, "chinhu ichi chisingawanzoitiki" chinowanikwa mu1-2% yevarwere veNSCLC. Mishonga inoshanda yakanangana nayo iripo, zvichiita kuti kuonekwa kwayo kuve kwakakosha.
-KRAS:Kare zvaionekwa se "zvisingashandisi mishonga," shanduko dzeKRAS dzakajairika. Kubvumidzwa kweKRAS G12C inhibitors kwachinja chiratidzo ichi kubva pachiratidzo chekufanotaura kuita chinangwa chinogona kuitwa, zvichichinja kutarisirwa kwevarwere ava.
MMT Portfolio: Yakagadzirwa kuti ive nechivimbo chekuongorora chirwere
Kuti ikwanise kuzadzisa chinodiwa chekuzivikanwa kwebiomarker chakarurama, MMT inopa portfolio yemakiti ekuona maPCR eCE-IVD ane marked real-time, imwe neimwe yakagadzirwa netekinoroji yepamusoro kuti ive nechokwadi chekuti kuongororwa kwechirwere kwacho kwakavimbika.
1. Kiti Yekuona Kushanduka kweEGFR
-Tekinoroji yeARMS Yakavandudzwa:Zvinowedzera simba remuviri zvinowedzera kuwedzera kwekuchinja kwemuviri.
-Kuwedzerwa kweEnzymatic:Zvidziviriro zve endonucleases zvinogaya mamiriro e genomic emhando yemusango, zvichiwedzera shanduko dzemutant uye zvinovandudza resolution.
-Kuvhara Tembiricha:Danho rekupisa rakati rinoderedza priming isina kujeka, zvichideredzawo mamiriro ekunze emusango.
-Mabhenefiti Akakosha:Kunzwa kusingaenzaniswi kwakaderera kusvika1%frequency yeallele yakachinja, kunyatsorongeka kwakanaka nekutonga kwemukati uye enzyme yeUNG, uye nguva yekukurumidza yekuchinja kweinengeMaminetsi zana nemakumi maviri.
- Inoenderana nezvese sampuli dze biopsy yenyama nedzemvura.
2. Kiti yeKuona Fusion yeMMT EML4-ALK
- Kunzwa Kwakanyanya:Inoona nemazvo fusion mutations ine muganho mudiki wekuona makopi makumi maviri/reaction.
-Kururama Kwakanaka Kwazvo:Inosanganisira mitemo yemukati yekudzora maitiro uye enzyme yeUNG kudzivirira kusvibiswa kunofamba, zvichidzivirira zvinobudirira zvinhu zvakanaka nezvakaipa zvenhema.
-Zviri Nyore & Zvinokurumidza:Iine mashandiro akarongeka, akavharwa nechubhu, anopedzwa mumaminitsi angangoita zana nemakumi maviri.
-Kuenderana kwezviridzwa:Inochinjika kune akasiyana maPCR zvishandiso zvinojairika panguva chaiyo, zvichipa mukana wekushandisa chero rabhoritari.
3. Kiti yeKuona Fusion yeMMT ROS1
Kunzwa Kwakanyanya:Inoratidza kushanda kwakanaka nekuona zvakavimbika makopi anosvika makumi maviri/kuita kwezvinangwa zvekubatanidza.
Kururama Kwakanaka Kwazvo:Kushandiswa kwezvinodzora zvemukati memuviri uye enzyme yeUNG kunovimbisa kuvimbika kwemhedzisiro yega yega, zvichideredza njodzi yekuzivisa zvikanganiso.
Zviri Nyore & Zvinokurumidza:Senzira yekuvhara machubhu, haidi matanho akaomarara ekuwedzera simba mushure mekuwedzera simba. Mhedzisiro chaiyo uye yakavimbika inowanikwa mumaminitsi angangoita zana nemakumi maviri.
Kuenderana kwezviridzwa:Yakagadzirirwa kushanda zvakanaka nemichina yakasiyana-siyana yePCR, zvichiita kuti zvive nyore kubatanidzwa mumashandiro ekushanda erabhoritari aripo.
4. Kiti yeKuona Kushanduka kweMMT KRAS
- Tekinoroji yeARMS yakagadziridzwa, yakasimbiswa neEnzymatic Enrichment uye Temperature Blocking.
- Kuwedzerwa kweEnzymatic:Inoshandisa restriction endonucleases kuti igaye genomic background yemhando yemusango, nokudaro ichivandudza mutant sequences uye ichivandudza zvakanyanya kugona kwekuona.
-Kuvhara Tembiricha:Inopa danho rekupisa rakati kuti rikonzere kusawirirana pakati pema primer chaiwo akachinja uye ma templates emhando ye wild, zvichideredza mamiriro ekumashure uye kuvandudza hunyanzvi hwawo.
- Kunzwa Kwakanyanya:Inowana mukana wekuona 1% yealleles dzakachinja, zvichiita kuti pave neruzivo rwekuti pane shanduko shoma.
-Kururama Kwakanaka Kwazvo:Mipimo yemukati yakabatanidzwa uye enzyme yeUNG inodzivirira kubva kumhedzisiro yenhema yakanaka neisina kunaka.
-Panera Rakazara:Yakagadzirwa zvakanaka kuti ibatsire kuona shanduko sere dzakasiyana dzeKRAS mumachubhu maviri chete ekuita reaction.
- Zviri Nyore & Zvinokurumidza:Inopa mhinduro dzakavimbika uye dzakavimbika mumaminitsi angangoita 120.
- Kuenderana kwezviridzwa:Inochinjika zvakanaka kumidziyo yakasiyana-siyana yePCR, ichipa hunyanzvi hwakasiyana-siyana mumarabhoritari ekiriniki.
Sei Uchifanira Kusarudza Mhinduro yeMMT NSCLC?
Yakakwana: Chikamu chakakwana chezvibodzwa zvina zvakakosha zveNSCLC.
Zvepamusoro paTekinoroji: Kuvandudzwa kwepfuma (Kuwedzera Enzymatic, Kuvhara Tembiricha) kunoita kuti ive nehunyanzvi uye kunzwisisika kwakanyanya pazvinonyanya kukosha.
Kukurumidza & Kushanda: Nzira yakafanana ~ 120-minute protocol mu portfolio yese inokurumidzisa nguva yekurapa.
Inochinjika uye Inowanikwa: Inoenderana nemhando dzakasiyana-siyana dzesampuru uye zvishandiso zvePCR, zvichideredza zvipingamupinyi zvekushandisa.
Mhedziso
Munguva yekuongorora kenza nenzira yakarurama, kuongorora mamorekuru ndiyo nzira inotungamira mafambiro ekurapa. Makit epamusoro ekuongorora eMMT anopa simba vanachiremba kuti vakwanise kuongorora mamiriro emuviri eNSCLC yemurwere nechivimbo, vachivhura mukana wekuponesa hupenyu hwemishonga yakanangwa.
Contact to learn more: marketing@mmtest.com
Nguva yekutumira: Gumiguru-14-2025