RSV vs. HMPV: Gwaro reVakiriniki reKuzivikanwa Kwazvo muVana

Ongororo yeClassic Research Pepa

Respiratory Syncytial Virus (RSV) uye Human Metapneumovirus (HMPV)nhamo dzine hukama hwepathogens mukati mePneumoviridaemhuriizvo zvinowanzovhiringika muzviitiko zvevana acute respiratory infection. Nepo mharidzo dzavo dzekiriniki dzichipindirana, data rekutarisisa (2016–2020) kubva kuzvipatara zvevana zvinomwe zveUS — zvinosanganisira varwere zviuru zvisere nemazana matanhatu neshanu — zvinoratidza mutsauko wakanyanya muhuwandu hwavo hwenjodzi huru, kuoma kwechirwere, uye manejimendi ekiriniki. Chidzidzo ichi chakashandisa dhizaini inoshanda, inotarisisa ine yakarongeka nasopharyngeal swab kuunganidza uye kuyedza 8 mavhairasi ekufema, ichipa yekutanga yakakura-yepasirese kuenzanisa kune vana chiremba. Nekuongorora mazinga ekurapwa muchipatara, ICU admissions, mechanical ventilation use, uye kugara kwenguva refu muchipatara (≥3 mazuva), inotangisa yakakosha pre-intervention epidemiological baseline yenguva yemajekiseni matsva eRSV (semuenzaniso, majekiseni ekudzivirira, anobata kwenguva refu monoclonal antibodies) uye inogadzira hurongwa hwekuvandudza HMPV remangwana.

Kutsvaga Kwakakosha 1: Maprofiles Akasiyana-akanyanya-Njodzi

-RSV inonyanya kubata vacheche vacheche:Nguva yepakati yekuiswa muchipatara yaingova mwedzi 7, uye 29.2% yevarwere vakagamuchirwa vari vacheche (0-2 mwedzi). RSV ndicho chikonzero chinotungamira chekuiswa muchipatara muvacheche vari pasi pemwedzi mitanhatu, nekuomarara kunoenderana nezera.

-HMPV inonangana nevana vakura nevaya vane comorbidities:Nguva yepakati yekuiswa muchipatara yaive mwedzi gumi nematanhatu, ine simba guru pavana vanopfuura gore rimwe. Zvinonyanya kukosha, kuwanda kwemamiriro ezvinhu ehutano (semuenzaniso, mwoyo, neurological, kufema) kwakapetwa kaviri pakukwirira kwevarwere veHMPV (26%) kana vachienzaniswa nevarwere veRSV (11%), vachiratidza kuwedzera kwekusagadzikana kwavo.

Mufananidzo 1. Kugoverwa kwezera rekushanyira ED uye zvipatarayakabatana neRSV kana HMPV

muvana vari pasi pemakore 18.

Kutsvaga Kwakakosha 2: Kusiyanisa Clinical Presentations

-RSV inoratidzira nezviratidzo zvakaderera zvekufema:Inonyatsobatanidzwa nebronchiolitis (76.7% yezviitiko zvechipatara). Zviratidzo zvakakosha zvinosanganisirachifuva madziro emadziro (76.9% inpatients; 27.5% ED)uyetachypnea (91.8% varwere; 69.8% ED), ese ari maviri zvakanyanya kakawanda kupfuura muHMPV.

-HMPV inopa nefivha yakanyanya uye njodzi yemabayo:Pneumonia yakaonekwa mu35.6% yevarwere vechipatara HMPV-kaviri chiyero cheRSV.Fivha ndiyo yainyanya kuoneka (83.6% inpatients; 81% ED). Kunyange zvazvo zviratidzo zvekufema zvakadai sekufema uye tachypnea zvichiitika, zvinowanzoita zvishoma kudarika muRSV.

Mufananidzo 2.Kuenzanisa maitiro uye kirinikichokwadiyeRSV vs. HMPV muvana vari pasi pemakore gumi nemasere.

Pfupiso: RSVChinonyanya kukonzera chirwere chakakomba muvacheche vacheche, chinoratidzwa nekunetseka kwakanyanya kwekufema (kufemereka, kudzokorora) uye bronchiolitis.HMPVrinowanzobata vana vakura vane comorbidities, rinoratidza kupisa kwakanyanya, rinotakura njodzi huru yepneumonia, uye rinowanzokonzera mhinduro yakakura yekuzvimba.

Kutsvaga Kwakakosha 3: Mwaka Patani Matter

-RSV ine yekutanga, inofanotaurwa peak:Chiitiko chayo chakanyanya kunangana, kazhinji chinokwira pakatiMbudzi naNdira, zvichiita kuti ive yekutanga kutyisidzira kwehutachiona kune vacheche mumatsutso nechando.

-HMPV inokwira gare gare nekusiyana kukuru:Mwaka wayo unosvika gare gare, kazhinji uchikwira mukatiMarch naApril, uye inoratidza kukosha kwegore negore uye kuchinja kwenharaunda, kazhinji kuoneka se "second wave" mushure mokunge RSV yaramba.

Mufananidzo 3.Pakazara uye saiti-yakananga PCR positivemazinga eRSV neHMPV pakati pevana vari pasi pemakore gumi nemasere vane acute respiratory infection (ARI) -yakabatana neED kushanyira uye kuchipatara.

Kudzivirira uye Kuchengeta: Chirongwa Chekuita Chinobva Pauchapupu

-RSV Prophylaxis:Nzira dzekudzivirira dzave kuwanikwa. Muna 2023, iyo US FDA yakabvumidza a refu-acting monoclonal antibody (Nirsevimab), inogona kudzivirira vacheche kwemwedzi yavo mishanu yekutanga. Pamusoro pezvo, kubaya kweRSV kwaamai kunofambisa zvinodzivirira masoja ekudzivirira chirwere kuvacheche vachangozvarwa.

-HMPV Prophylaxis:Parizvino hapana mishonga yekudzivirira inobvumirwa. Nekudaro, vaccine vakati wandei (semuenzaniso, AstraZeneca's RSV/HMPV musanganiswa wejekiseni) vari mumiedzo yekiriniki. Vabereki vanorayirwa kuti vagare vachiziva nezvekuvandudzwa kubva kuvakuru vehutano hweveruzhinji.

Tsvaka Kurumidza Kutarisirwa Kurapwa kune IMWE yeiyi "Red Mireza":

-Fever muVacheche:Tembiricha ≥38°C (100.4°F) mumwana ari pasi pemwedzi mitatu yekuberekwa.

-Kukwidziridzwa Kwekufema:Kufema kunopfuura kufema kwe60 paminiti kune vacheche mwedzi 1-5, kana 40 kufema paminiti yevana vane makore 1-5, zvichiratidza kuti vanogona kufema kunetseka.

-Low Oxygen Saturation:Oxygen saturation (SpO₂) inowira pasi pe90%, chiratidzo chakakomba chehurwere hwakanyanya hunoonekwa mu30% yeRSV uye 32.1% yeHMPV zvipatara zviitiko mukudzidza.

-Lethargy kana Kudyisa Matambudziko:Kunooneka kuneta kana kudzikiswa kwemukaka nekanopfuura chikamu chimwe muzvitatu mukati meawa makumi maviri nemana, izvo zvinogona kuva nhanho yekudonha mvura.

Kunyange zvakasiyana muchirwere chechirwere uye kuratidzwa kwekiriniki, kunyatsosiyanisa pakati peRSV neHMPV padanho rekutarisira kunoramba kuchinetsa. Uyezve, njodzi yekiriniki inopfuurira kupfuura aya mavhairasi maviri, ane utachiona hwakadai sefuruwenza A uye huwandu hwemamwe hutachiona hwehutachiona uye hwehutachiona panguva imwe chete huchityisidzira hutano hwevanhu. Panguva uye chaiyo etiological kuongororwa kwakakosha kune kwakakodzera kutsigira manejimendi, inobudirira kuzviparadzanisa nevamwe, uye zvine musoro zviwanikwa kugoverwa.

Kuunza iyo AIO800 + 14-Pathogen Yakasanganiswa Detection Kit (Fluorescence PCR)(NMPA, CE, FDA, SFDA yakabvumidzwa)

Kuti isangane nechikumbiro ichi, theEudemon ™ AIO800 Yakazara Otomatiki Nucleic Acid Detection System, yakasanganiswa a14-pathogen kufema panhizha, inopa mhinduro yekushandura - kuendesa chokwadi"Sample in, pindura"diagnostics mumaminitsi makumi matatu chete.

Iyi yakazara kufema bvunzo inoonas zvose mavhairasi uye mabhakitiriyakubva pamuenzaniso mumwe chete, zvichiita kuti vemberi vezvehutano vape vatapi vezvehutano vaite sarudzo dzehushingi, nenguva, uye dzakanangwa dzekurapa.

Makiyi Sisitimu Mamiriro Akakosha kune Vatengi Vako

 Fully Automated Workflow
Asingasviki 5 maminitsi maoko-panguva. Hapana chikonzero chevashandi vane hunyanzvi hwema molecular.

- Fast Results
Nguva yekuchinja yemaminetsi makumi matatu inotsigira zvirongwa zvekiriniki nekukurumidza.

- 14Pathogen Multiplex Detection
Kuzivikanwa panguva imwe chete kwe:

Utachiona:COVID-19,Influenza A & B,RSV,Adv,hMPV,Rhv,Parainfluenza marudzi I-IV,HBoV,EV,CoV

Utachiona:MP,Cpn,SP

-Lyophilized Reagents Yakagadzikana paTembiricha yemumba (2–30°C)
Inorerutsa kuchengetedza uye kufambisa, kubvisa kutonhora-kutsamira.

Robust Contamination Prevention System
11-layer anti-kusvibiswa matanho anosanganisira UV sterilization, HEPA kusefa, uye yakavharwa-cartridge workflow, nezvimwe.

Kukurumidza, kutariswa kwepathogen kwakadzika kunova hwaro kukutonga kwemazuva ano kwezvirwere zvekufema kwevana. Iyo AIO800 sisitimu, ine yakazara otomatiki, maminitsi makumi matatu, multiplex PCR pani, inopa mhinduro inoshanda kune yekumberi marongero. Nekugonesa kuonekwa kwekutanga uye kwakaringana kweRSV, HMPV, uye mamwe hutachiona akakosha, inopa simba varapi kuita sarudzo dzakanangana dzekurapa, kugadzirisa mashandisirwo emishonga inorwisa mabhakitiriya, uye kuita kudzora hutachiona hunobudirira-kuzovandudza kutarisirwa kwevarwere uye hutano hwehutano.

#RSV #HMPV #Kukurumidza #Identification #Kufemerwa #Pathogen #Sample-ku-Mhinduro#MacroMicroTest