Imwe mhando yefuruwenza ichangobva kubuda—Furuwenza A(H3N2) Subclade K—iri kukonzera huwandu hwakawanda hwefuruwenza munzvimbo dzakasiyana-siyana, zvichiisa kumanikidzwa kukuru pahurongwa hwehutano hwepasi rose. Panguva imwe chete, hunyanzvi hwekuongorora hunobva pakuongorora maantigen nekukurumidzakukuyedzwa kwemamorekuru kwakazara otomatikikukutevedzana kwemajini akazaravari kuchinja patsva mawaniro atinoita, kusimbisa, uye kunzwisisa njodzi dziri kuchinja dzehutachiona.
Pamwe chete, izvi zvinoratidza shanduko kuenda kune nzira yakanyatsojeka uye ine zvikamu zvakasiyana-siyana yekutarisira zvirwere zvinotapukira zvekufema.
Musiyano Unochinja Mutambo: Chii Chinoita Kuti Subclade K Isiyane?
Subclade Kinomiririra bazi idzva remajini mukati merudzi rweH3N2, rakaumbwa nekuchinja-chinja kuri kuitika muprotein yehemagglutinin (HA). Kunyange hazvo kutenderera kweantigenic kuchitarisirwa, Subclade K yakakurumidza kuzvisiyanisa kuburikidza nezvinhu zviviri zvakakosha:
Kupukunyuka Kwemuviri Wekudzivirira Kurwara
Kuchinja kukuru kweHA kunochinja chimiro cheantigen chehutachiona, zvichideredza kufanana kwahwo ne:
-Mishonga inosanganisirwa mumajekiseni efuruwenza aripo iye zvino
-Kudzivirirwa kwezvirwere kubva kuzvirwere zvitsva
Izvi zvinoita kuti huwandu hwezvirwere zvinopararira huwedzere.
Kugwinya Kwakawedzerwa Kwekufambisa
Kuchinja kwechimiro chemuviri kunogona kuvandudza kugona kwehutachiona kubatana nema receptors ari muchikamu chepamusoro chekufema, zvichipa Subclade K mukana wekukwikwidzana mukutapurirana.
Mhedzisiro Yenyika Yose
Ruzivo rwekuchengetedzwa kwenyika kubva kunyika dzeAsia neEurope runoratidza kuti Subclade K ndiyo inoongorora huwandu hwenyaya dzakaitika.pamusoro pe90%kuwanikwa kweH3N2 munguva pfupi yapfuura. Kupararira kwayo nekukurumidza kwakakonzera mwaka wekutanga wefuruu uye mutoro wehutano wakawedzera, zvichiratidza kudiwa kwenzira dzakasiyana dzekuongorora dzakagadzirirwa nzvimbo dzekiriniki, dzemunharaunda, uye dzehutano hweveruzhinji.
Chirongwa Chekuongorora Matambudziko Evanhu Vatatu muSubclade K
Mhando yefuruwenza inoshanduka nekukurumidza inoda anzira yekuongorora ine matanho akasiyana, inopindiranaizvo zvinogonesa:
-Kuongororwa nekukurumidza munzvimbo dzemunharaunda
-Kusimbiswa nekukurumidza uye kwakarurama munzvimbo dzekiriniki
-Kuongorora kwakadzama kwemajini kwekutarisa nekutsvaga
Pazasi pane hurongwa hwakabatanidzwa hwemhinduro nhatu.
1.Kukurumidza Kuongorora:inochinjika 2~6-mu-1Kuedzwa kweAntigen (Immunochromatography)
Yakanakira:
Makiriniki ekutarisira varwere vekutanga, madhipatimendi ekurapwa kunze kwechipatara, makamuri ehutano echikoro, makiriniki ebasa, uye kuzviongorora wega kumba.
Nei zvichikosha:
Mamiriro aya anoda kuongororwa nekukasika uye zvisarudzo nekukurumidza kudzivirira kupararira uye kutungamira matanho anotevera.
Zvinhu Zvikuru:
-Kushanda kuri nyore, kusina michina
-Mhedzisiro inowanikwa muMaminetsi gumi nemashanu
Inobatsira kukurumidza kuziva hutachiona hweInfluenza A & B kana humwe hutachiona hwekufema hunowanzoonekwa.
Bvunzo iyi inoumbanzira yekutanga yekuona nharaunda, zvichibatsira kukurumidza kuona vanhu vanofungidzirwa kuti vane chirwere ichi uye kuona kana zvichidikanwa kusimbisa mamorekuru.
1.Kusimbiswa Kwemamorekuru Nekukurumidza: AIO800 Yakagadzirwa ZvizereMolecularSisitimu yekuona+14-mu-1 Kit Yekuona Kufema
Yakanakira:
Madhipatimendi ekukurumidzira muzvipatara, mawadhi evarwere vari muchipatara, makiriniki efivha, uye marabhoritari ekuongorora chirwere munharaunda.
Nei zvichikosha:
Zvichienderana nekuti Subclade K inopukunyuka sei immune system uye kuti zviratidzo zvayo zvinosangana sei nezvimwe zvirwere zvinotapukira, kuziva kwakanyatsojeka kwakakosha kuti:
-Kusarudza mishonga inorwisa mavhairasi yakaita seoseltamivir
-Kusiyanisa furuwenza neRSV, adenovirus, kana zvimwe zvirwere
-Kuita sarudzo dzekuenda kuchipatara nekukurumidza kana dzekuzviparadzanisa nevamwe
Zvinhu Zvikuru:
-Ichokwadi "muyedzo wekupinda, mhedzisiro" yekushanda otomatiki zvizere
-Inoburitsa mhedzisiro yekuyedzwa kwe nucleic acid muMaminetsi 30–45
-Mapanera ePCR akawanda panguva chaiyo anoona14utachiona hwekufemakunyangwe paine huwandu hwehutachiona hwakaderera zvakanyanya.
Iyo AIO800 inoshanda sechikamu chemusimboti wekirinikikuongororwa kwefuruwenza yemazuva ano, zvichiita kuti pave nekusimbiswa nekukurumidza uye kwakarurama uye kutsigira kuongororwa kwehutano hweveruzhinji panguva chaiyo.
3. Kuferefeta Kwakadzika Kwehutachiona: Kutevedzana Kwakazara Kwemavhairasi Efuruu
Yakanakira:
Nzvimbo dzeKudzora Zvirwere, masangano ekutsvagisa, nzvimbo dzekutarisa mavhairasi, uye marabhoritari ehutano hweveruzhinji enyika kana matunhu.
Nei zvichikosha:
Subclade K—nemamwe marudzi emangwana—anofanira kugara achiongororwa padanho remajini kuti anzwisise:
-Kudonha kwemakemikari mumuviri
-Kuchinja kwekusagona kurwisa mavhairasi
-Kubuda kwemarudzi matsva
-Mambure ekutapurirana uye mavambo echirwere
Zvinhu Zvikuru:
-Basa rekupedzisira kubva pakuburitsa sampuro kusvika pakugadzirira raibhurari, kutevedzana, uye kuongorora bioinformatics
-Inopa magenes ese ehutachiona
-Inobvumira kuongororwa kwemaprofiles ekuchinja, miti yephylogenetic, uye kushanduka-shanduka kwezvinhu
Kutevedzana kwemajini ese kunomiririrachikamu chakadzama chekuongorora, zvichipa ruzivo runobatsira pakuvandudzwa kwemishonga inorwisa majekiseni, sarudzo dzemitemo, uye pasi rose
hurongwa hwekutarisa.
Kuenda kuSistimu Yekudzora Furuwenza Inotungamirirwa Nemazvo
Kubatanidzwa kwenjodzi yehutachiona iri kuchinja nekukurumidza uye matekinoroji epamusoro ekuongorora chirwere kuri kutungamira shanduko muhurongwa hwehutano hweveruzhinji.
1. Kubva paKufungidzira Kwakavakirwa paZviratidzo kusvika paKuedza Kwakanyatsorongwa
Kuongororwa kweAntigen → kusimbiswa kwemamorekuru → kuteverwa kwemajini kunoumba nzira yakakwana yekuongorora.
2. Kubva paKupindura Kwemhinduro kuenda paKuziva Nenguva Yechokwadi
Kuongororwa nekukurumidza nguva nenguva uye data re genomic rinoenderera mberi rinotsigira yambiro dzekutanga uye kugadzirisa mutemo unochinja.
3. Kubva paZviyero Zvakapatsanurwa Kuenda kuKudzora Kwakabatana
Kubaiwa nhomba, kuongororwa nekukurumidza, kurapwa nemavhairasi, uye kupindira kwehutano hweveruzhinji zvinogadzira nzira yekudzivirira yakabatana.
Mukati mehurongwa uhu, bvunzo yeantigen inopasefa yepamberi, iyo AIO800 inopakunyatsojeka kwekiriniki, uye zvinopihwa zvekutevera ma genome akazaraudzamu hwehurongwa—pamwe chete vachiumba dziviriro yakasimba kubva kuSubclade K uye mhando dzefuruwenza yeramangwana.
Nguva yekutumira: Zvita-10-2025