Clostridioides difficile inoramba iri imwe yezvirwerezvikonzero zvikuru zvemanyoka anokonzerwa nehutanopasi rose. Mutoro uyu wakakosha zvikuru pakati pevarwere vakwegura, vanhu vari muzvipatara, vagari venzvimbo dzinochengetwa varwere kwenguva refu, uye varwere vanowana mishonga inorwisa mabhakitiriya yakawanda.
Asi kuongorora chirwere cheC. difficile (CDI) kunopa dambudziko rakasiyana.
Kusiyana nezvirwere zvakawanda zvemudumbu, C. difficile ndiyochirwere chinopa mukana wekuwana mukanazvinogona kugara mudumbu pasina kukonzera chirwere. Kutakura kusina zviratidzo kunowanzoonekwa munzvimbo dzehutano, zvichireva kuti kuvapo kwechinhu ichi chete hazvirevi kuti chine hutachiona.
Musiyano uyu pakati pekupararira kwezvirwere nekupararira kwezvirwere ndiwo musimboti wekuongorora kweCDI kwemazuva ano.
Chii chinonzi CDI?
Chirwere chinokura kana mhando dzetoxin dzichigadzira chepfu dzinokuvadza mucosa yemudumbu, zvichikonzera zviratidzo zvakaita se:
- Manyoka asina kutsanangurwa
- · Kurwadziwa kwemudumbu
- · Kupindwa nechando
- · Leukocytosis
- · Colitis
Zvichienderana negwaro reEuropean Society of Clinical Microbiology and Infectious Diseases (ESCMID) ra2021, kuongororwa kwemurabhoritari kunofanirwa kuitwa zvakanyanya kune varwere vane manyoka akakosha anoratidza CDI.
Gwaro iri rinotsanangura manyoka setsvina nhatu kana kupfuura mukati memaawa makumi maviri nemana uye rinosimbisa kuti zvakawanikwa murabhoritari zvinofanira kugara zvichiitwa.inofanira kududzirwa pamwe chete nezviratidzo zvekiriniki.
Mhedzisiro yakanaka yerabhoritari chete haifanirwe kuenzaniswa neCDI otomatiki.
ESCMID: Kusanganisa Kuongorora Kliniki uye Kuongororwa muRabhoritari
Kuti vawedzere kururama kwekuongororwa kwechirwere uku vachideredza kuongororwa kwechirwere zvakanyanya, ESCMID inokurudzira nzira yekuongorora chirwere nenzira dzakawanda.
Danho rekutanga rekuongorora rinogona kushandisa:
- · Glutamate dehydrogenase (GDH), kana
- · Kuedzwa kweNucleic Acid Amplification (NAAT)
Nzira dzose dziri mbiri dzinopa mukana wekuona varwere vane C. difficile.
Zvichienzaniswa neGDH,NAAT inopa hunyanzvi hwakavandudzwa nekuona majini ane chekuita nehupfu anotakurwa nemarudzi ane chepfupane kungoziva kuti chipenyu chacho chiripo here.
Zvisinei, ESCMID inotaurawo kuti kuvimba neNAAT chete kunogona kukonzera kuongororwa kwakawandisa kwechirwere ichi nekuti majini emuchetura anogona kuonekwa muvanhu vane zviratidzo zvechirwere ichi kana varwere vasina chirwere chakakodzera kurapwa.
Nekuda kwechikonzero ichi, mhedzisiro yekuongorora yakanaka inodudzirwa zvakanaka pamwe chete nemhedzisiro yekuongorora kwetoxin immunoassay uye zvakawanikwa mukiriniki.
Nzira iyi inobatsira kusiyanisa:
- · CDI inoshanda
- · Kugara mudzimba dzisina zviratidzo
- · Kutapukirwa kwekutanga kunoda kuongororwa kwakawanda kwekiriniki
Kuedza CDI Yakabatana Nenhungamiro
Kutsigira marabhoritari ari kuita kuongorora mamorekuru mukati menzira dzekuongorora maCDI, Macro & Micro-Test inopaKiti yeKuona Nucleic Acid yeClostridium difficile Toxin A/B Gene (Fluorescence PCR).
Muedzo uyu unoona zvakanangatcdAuyetcdBmajini kubvazviyereso zvetsvina zvisina kuumbwa, zvichiita kuti zvikwanise kukurumidza kuziva mhando dzeC. difficile dzine chepfu.
Zvakanakira Zvikuru:
-Kunzwa kwakanyanya kwemuviri neLoD yakaderera se:200 CFU/mL/2,000 makopi/mL, zvichiita kuti zvikwanisike kuona mhando dzetokisi dzakaderera.
-Kutsvaga chepfu A (tcdAuye chepfu B (tcdB) majini, bvunzo iyi inonyatsoona marudzi anokwanisa kugadzira zvinhu zvikuru zvine chekuita nehutachiona zvine chekuita neCDI.
- Kubatanidzwa kweKufamba Kwebasa Kunochinjika: kunoenderana nemapuratifomu ePCR enguva chaiyo uye Kuedzwa Kwese Kwega paEudemon AIO 800
-IVDR certification, ichiratidza kutevedzera zvinodiwa zvakasimba zveEuropean In Vitro Diagnostic Regulation uye inotsigira marabhoritari mumisika yeEurope neyepasi rose.
Kugonesa Sarudzo Dziri Nani dzeKliniki
Kuongororwa kweCDI nemazvo kunoda zvinopfuura kungoona cheteC. zvakaomaZvinoda kubatanidzwa kwezviratidzo zvekiriniki, zvakawanikwa murabhoritari, uye kunzwisisa musiyano uripo pakati pekupararira kwechirwere ichi nehutachiona.
Zvichienderana nezvinodiwa neESCMID, NAAT ine hunhu hwakanyanya uye ine basa rakakosha pakuona chepfu.C. zvakaomamatambudziko sechikamu chehurongwa hwakazara hwekuongorora CDI.
Kuburikidza nemhinduro dzayo dzekuongorora mamorekuru dzakasimbiswa neIVDR, Macro & Micro-Test yakazvipira kubatsira marabhoritari kupa mhedzisiro inokurumidza uye yakavimbika inotsigira sarudzo dzekiriniki dzine ruzivo, matanho anoshanda ekudzivirira hutachiona, uye mhedzisiro yemurwere iri nani.
Nguva yekutumira: Chikumi-25-2026