Mishonga Yekuchengetedza Aspirin

Aspirin, semushonga unoshanda wekudzivirira kuunganidzwa kweplatelet mumuviri, unoshandiswa zvakanyanya mukudzivirira nekurapa zvirwere zvemwoyo netsinga dzeropa. Ongororo iyi yakawana kuti vamwe varwere vakawanikwa vasingakwanise kudzivirira kushanda kwemaplatelet kunyangwe vachishandisa aspirin kwenguva refu, kureva kuti, kuramba aspirin (AR). Chiyero chacho chiri pakati pe50%-60%, uye kune misiyano iri pachena yemarudzi. Glycoprotein IIb/IIIa (GPI IIb/IIIa) inoita basa rakakosha mukuunganidzwa kweplatelet uye thrombosis panzvimbo dzakakuvara dzetsinga. Zvidzidzo zvakaratidza kuti magene polymorphisms anoita basa rakakosha mukuramba aspirin, kunyanya kutarisa paGPIIIa P1A1/A2, PEAR1 uye PTGS1 gene polymorphisms. GPIIIa P1A2 ndiyo gene guru rekuramba aspirin. Kuchinja kwegene iri kunochinja chimiro cheGPIIb/IIIa receptors, zvichikonzera kubatana pakati pemaplatelet nekubatanidzwa kweplatelet. Ongororo iyi yakawana kuti kuwanda kweP1A2 alleles muvarwere vasingadi aspirin kwakakwira zvakanyanya kupfuura kwevarwere vane aspirin, uye varwere vane P1A2/A2 homozygous mutations havana kushanda zvakanaka mushure mekutora aspirin. Varwere vane mutant P1A2 alleles vari kupihwa stenting vane subacute thrombotic event rate yakapetwa kashanu pane yevarwere veP1A1 homozygous wild-type, vachida madosi akawanda easpirin kuti vawane mhedzisiro yeanticoagulant. PEAR1 GG allele inopindura zvakanaka kuaspirin, uye varwere vane AA kana AG genotype vanotora aspirin (kana pamwe chete ne clopidogrel) mushure mekuisirwa stent vane myocardial infarction yakakura uye kufa. PTGS1 GG genotype ine njodzi yakakura yekusada aspirin (HR: 10) uye kuwanda kwezviitiko zvemwoyo (HR: 2.55). AG genotype ine njodzi iri pakati nepakati, uye kutarisisa kwakasimba kunofanirwa kupihwa kumhedzisiro yekurapwa kweaspirin. AA genotype inonyanya kubatwa neaspirin, uye kuwanda kwezviitiko zvemwoyo kwakaderera. Mhedzisiro yekuona chigadzirwa ichi inongomiririra chete mhedzisiro yekuona majini ePEAR1, PTGS1, uye GPIIIa evanhu.